The overall mission of the Virology/Immunology Core is to enhance HIV-related research andpromote collaborations among HIV investigators, by providing improved access to virologic andimmunologic assays, clinical specimens, and recombinant DMA constructs.
The specific aims of this Core are:1. To provide a centralized repository for clinical specimens and HIV-related recombinant DMAconstructs that can be used by clinical, behavioral, and laboratory investigators.2. To centralize, and improve access to, state-of-the-art virologic assays for clinical, behavioral,and laboratory investigators.3. To provide a centralized facility that produces recombinant proteins relevant to HIV research.4. To provide expertise in the design and interpretation of flow cytometry assays, and to improveaccess to the shared instrumentation necessary to conduct these studies.5. To provide improved access to existing URMC core facilities.This core will utilize and augment already existing infrastructures, such as those in the Cold StorageFacility (Aim 1), Infectious Diseases Unit laboratories (Aim 2), Human Immunology Center (Aim 4), andexisting core facilities (Aim 5) at the URMC. In addition, we will centralize expression of certainrecombinant proteins (Aim 3), in order to provide economy of scale to investigators that use them in HIVrelatedresearch. The Virology/Immunology Core will implement the overall mission of the UR D-CFARby supporting a broad base of investigators from the UR and its international collaborators in SouthAfrica, and promoting interdisciplinary collaborations among them.
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