Abstract

; The Clinical and Translational Sciences Core (CTSC;Core C) will provide key services to UR investigators to promote collaborative clinical and translational HIV/AIDS research. The objective of the Core is to efficiently provide UR HIV/AIDS investigators direct access to human subjects research, a discipline that can be dauntingly complex and time-consuming for new investigators (including early-stage investigators, investigators new to HIV/AIDS, and basic science HIV/AIDS investigators wishing to conduct translational research). It will do so by leveraging existing infrastructure, resources and expertise, at modest incremental cost, to create broad synergies that can make a major impact on clinical and translational studies. Our experience as a D-CFAR has shown that providing that access to services alone is not necessarily sufficient to encourage new investigators to undertake translational HIV/AIDS projects. This has led us to develop a highly proactive, user-oriented, innovative approach, that includes consultation, advice and even identification and recruitment of study subjects (

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI078498-06
Application #
8520713
Study Section
Special Emphasis Panel (ZAI1-UKS-A (J1))
Project Start
2008-05-01
Project End
2018-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
6
Fiscal Year
2013
Total Cost
$240,162
Indirect Cost
$99,679

  Institution

Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Piekna-Przybylska, Dorota; Nagumotu, Kavyasri; Reid, Danielle M et al. (2018) HIV-1 infection renders brain vascular pericytes susceptible to the extracellular glutamate. J Neurovirol :
Braksmajer, Amy; Simmons, Janie; Aidala, Angela et al. (2018) Effects of Discrimination on HIV-Related Symptoms in Heterosexual Men of Color. Am J Mens Health 12:1855-1863
Loelius, Shannon G; Lannan, Katie L; Blumberg, Neil et al. (2018) The HIV protease inhibitor, ritonavir, dysregulates human platelet function in vitro. Thromb Res 169:96-104
Loelius, Shannon G; Spinelli, Sherry L; Lannan, Katie L et al. (2018) In Vitro Methods to Characterize the Effects of Tobacco and Nontobacco Products on Human Platelet Function. Curr Protoc Toxicol 76:e46
Rice, John D; Strawderman, Robert L; Johnson, Brent A (2018) Regularity of a renewal process estimated from binary data. Biometrics 74:566-574
Nogales, Aitor; Piepenbrink, Michael S; Wang, Jiong et al. (2018) A Highly Potent and Broadly Neutralizing H1 Influenza-Specific Human Monoclonal Antibody. Sci Rep 8:4374
Zhou, Tian; Su, Hang; Dash, Prasanta et al. (2018) Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials 151:53-65
Horita, Yasuhiro; Alsultan, Abdullah; Kwara, Awewura et al. (2018) Evaluation of the Adequacy of WHO Revised Dosages of the First-Line Antituberculosis Drugs in Children with Tuberculosis Using Population Pharmacokinetic Modeling and Simulations. Antimicrob Agents Chemother 62:
Yang, Hongmei; Holden-Wiltse, Jeanne; Topham, David J et al. (2018) Maximum Likelihood Estimation of Titer via a Power Family of Four-Parameter Logistic Model. J Biopharm Stat 28:492-500
Belashov, Ivan A; Crawford, David W; Cavender, Chapin E et al. (2018) Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription. Nucleic Acids Res 46:6401-6415

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