Project Start
1984-09-30
Project End
1985-11-30
Budget Start
1984-09-30
Budget End
1985-11-30
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Meng, F; Wei, Q; Hoversten, M T et al. (2000) Switching agonist/antagonist properties of opiate alkaloids at the delta opioid receptor using mutations based on the structure of the orphanin FQ receptor. J Biol Chem 275:21939-45
Meng, F; Ueda, Y; Hoversten, M T et al. (1998) Creating a functional opioid alkaloid binding site in the orphanin FQ receptor through site-directed mutagenesis. Mol Pharmacol 53:772-7
Bagnol, D; Mansour, A; Akil, H et al. (1997) Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract. Neuroscience 81:579-91
Cho, W; Taylor, L P; Akil, H (1996) Mutagenesis of residues adjacent to transmembrane prolines alters D1 dopamine receptor binding and signal transduction. Mol Pharmacol 50:1338-45
Meng, F; Taylor, L P; Hoversten, M T et al. (1996) Moving from the orphanin FQ receptor to an opioid receptor using four point mutations. J Biol Chem 271:32016-20
Watson, B; Meng, F; Akil, H (1996) A chimeric analysis of the opioid receptor domains critical for the binding selectivity of mu opioid ligands. Neurobiol Dis 3:87-96
Meng, F; Ueda, Y; Hoversten, M T et al. (1996) Mapping the receptor domains critical for the binding selectivity of delta-opioid receptor ligands. Eur J Pharmacol 311:285-92
Caamano, C A; Morano, M I; Dalman, F C et al. (1995) Point mutations in the 90-kDa heat shock protein binding region of the glucocorticoid receptor affect the functional characteristics of the receptor. Ann N Y Acad Sci 761:403-4
Meng, F; Hoversten, M T; Thompson, R C et al. (1995) A chimeric study of the molecular basis of affinity and selectivity of the kappa and the delta opioid receptors. Potential role of extracellular domains. J Biol Chem 270:12730-6
Cho, W; Taylor, L P; Mansour, A et al. (1995) Hydrophobic residues of the D2 dopamine receptor are important for binding and signal transduction. J Neurochem 65:2105-15

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