The Morphology Core (Core A) has existed since the beginning of the SDRC at our institution. It has beenconsistently a heavily utilized Core providing a diverse array of services to a large number of SDRC facultyand their associates. In the current proposal, the principal aim of the CMMC is to continue to provide stateof-the-art services and expertise to SDRC investigators using a wide variety of morphological andimmunologic studies in which microscopic analysis plays a central role. The SDRC faculty responsible forMorphology operations provides access to highly trained technical personnel in very well equipped researchlaboratories. An additional goal is to foster exchange of technical information among SDRC members and toencourage the sharing of resources. Key features of this core are its flexibility in adapting to the evolvingneeds of SDRC faculty, and its comprehensive and innovative range of services designed to support theneeds of both proposed and future SDRC-related morphological studies. These services fall into threeSpecific Aims with one new service not previously available to SDRC investigators (Ix)'Aim I. To provide state-of-the-art services, expertise and cost savings (i) embedding, sectioning, andstaining facilities and routine histology services ; (ii) immunolocalization methods for morphological studies(iii) microscopy, photomicroscopy with expert-guided hands-on training in a range of microscopictechnologies; (iv) expert pathologic interpretation of microscopy of human and mouse tissue; design ofexperiments requiring morphology analysis; (v) image analysis; (vi) confocal laser microscopy ;(vii) lasercapture microscopy ; (viii) flow cytometry analysis; (ix) small animal imaging (new);
Aim II. To provide morphologic techniques and expertise that facilitate a 'pipeline' of translational researchand interdisciplinary projects involving skin research.
Aim III. To promote career development with a skin-centered emphasis for research residents, fellows andfaculty members by helping them to learn state of the art morphologic techniques as they build a body ofpreliminary data for research projects. We have a demonstrated track history in Morphology Core support forthese three Specific Aims.
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