The SCID mouse: The skin xenograft core has developed methods to routinely generate severe combinedimmunodeficient (SCID) beige (bg) double mutant mice engrafted with human skin in the form of split thicknessskin grafts or with synthetic skin constructs incorporating human skin cells. The three specific aims of thecore are (1) to provide members of the YSDRC (both established and junior investigators, and especiallyinvestigators with YSDRC P/F projects) with limited numbers of C.B-17 SCID/beige mice engrafted withhealthy adult human skin or skin constructs for establishing the utility of these models for specific skindisease-related studies; (2) to train members of the YSDRC to generate such mice once feasibility has beenestablished; and (3) to develop variant models of this technique for new and novel applications, specificallyfocusing on synthetic skin equivalents constructed from distinct populations of cells both from patients withspecific skin diseases and/or that may be genetically modified to alter biologic functions. The core will alsocontinue evaluating alternative mouse recipient strains and methods to combine human skin grafts withelements of the human hematopoietic system to better model inflammatory skin disorders and responses toskin infections.
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