The Emory Skin Disease Research Core Center (ESDRC) will foster, coordinate and enhance collaborative efforts among 24 clinical and basic scientistic from a wide range of research disciplines. Their expertise will be focused on mechanisms of cutaneous disease as well as cutaneous biology, with special emphasis on the role of the cutaneous microvasculature in these processes. This emphasis will take advantage of an outstanding, multidisciplinary group of endothelial cell biologists, many of whom have never before focused their expertise on the skin. Combined with the expertise and experience of the investigators in the Department of Dermatology, this group of scientists centered at the ESDRC will provide novel insights into the role of cutaneous microvascular endothelial cells in a variety of skin-related biologic and pathologic processes, including acute and chronic inflammation, wound healing, angiogenesis, vasculitis, Kaposi's sarcoma, and tumor metastasis. Capitalizing upon the diversity of expertise and existing Emory research centers and services, the ESDRC will be organized into three scientific cores: 1) the Tissue Culture and Antibody Production Core; 2) the Microchemical Component; and c) a Flow Cytometry/Cell Sorting Component; and finally 3) the analytical approaches, a diversity of expertise, and continuous training for all ESDRC investigators and the research fellows in their laboratories. As a consequence, these facilities will greatly enhance the productivity of participating investigators. Additionally, six pilot and feasibility studies have been selected from a group of 13 submitted for review. All of them are focused on dermal microvascular cells and demonstrate application of a broad spectrum of expertise, techniques,and scientific rationale not currently being utilized in the study of cutaneous biology in general, and the dermal microvasculature in particular. Additionally, a comprehensive and multidisciplinary Enrichment Program will provide regular seminars, workshops, and visiting scientist presentations that will greatly enhance the research and educational environment at Emory. The long term goals of the ESDRC are to provide novel insights and approaches into cutaneous pathologic and physiologic processes through fostering and coordinating a multidisciplinary research approach among a variety of nationally recognized investigators and their laboratories.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR042687-10
Application #
6645379
Study Section
Special Emphasis Panel (ZAR1-AAA-C (J1))
Program Officer
Baker, Carl
Project Start
1994-03-01
Project End
2006-04-30
Budget Start
2003-05-01
Budget End
2006-04-30
Support Year
10
Fiscal Year
2003
Total Cost
$618,000
Indirect Cost
Name
Emory University
Department
Dermatology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Arbiser, Jack L; Bonner, Michael Y; Gilbert, Linda C (2017) Targeting the duality of cancer. NPJ Precis Oncol 1:
Pleniceanu, Oren; Shukrun, Racheli; Omer, Dorit et al. (2017) Peroxisome proliferator-activated receptor gamma (PPAR?) is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic target EMBO Mol Med 9:508-530
Díaz, Begoña; Ostapoff, Katherine T; Toombs, Jason E et al. (2016) Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an orthotopic model. Oncotarget 7:51569-51580
Laidlaw, Kamilla M E; Berhan, Samuel; Liu, Suhu et al. (2016) Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia. Oncotarget 7:51651-51664
Bhandarkar, Sulochana S; Lanka, Padmavathy; Lanka, Lakshmana Rao et al. (2016) Tuberculosis verrucosa cutis lesions exhibit a greater microvessel count than lupus vulgaris lesions. Exp Dermatol 25:479-80
Costa, Adilson; Bonner, Michael Yi; Arbiser, Jack L (2016) Use of Polyphenolic Compounds in Dermatologic Oncology. Am J Clin Dermatol 17:369-85
Bonner, Michael Y; Karlsson, Isabella; Rodolfo, Monica et al. (2016) Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo. Oncotarget 7:12857-68
Arbiser, Jack L; Bonner, Michael Y (2016) Seborrheic Keratoses: The Rodney Dangerfield of Skin lesions, and Why They Should Get Our Respect. J Invest Dermatol 136:564-566
Arbiser, Jack L (2014) PHIPing out: a genetic basis for tumor ulceration. J Invest Dermatol 134:600-602
Spence-Shishido, Allyson; Carr, Christopher; Bonner, Michael Y et al. (2013) In vivo Gram staining of tinea versicolor. JAMA Dermatol 149:991-2

Showing the most recent 10 out of 131 publications