This competing renewal application for the Columbia University Medical Center Skin Disease Research Core Center Grant (CUMCSDRC) requests support for the purpose of sustaining and building a focus of excellence in cutaneous biology at Columbia University that will leverage the considerable existing research strength within the Department of Dermatology and harness it to the rich opportunities for collaborative research with talented investigators throughout the institution and the New York region. We have selected three Themes, stem cells, skin and neuroscience, and genetics and immunology, which have outstanding potential to link basic science advances in these areas to a better understanding of the mechanisms of human skin disease thereby offering real promise for finding innovative strategies for the prevention and treatment of these disorders. This proposal is supported by three highly innovative cutting edge Core facilities designed to provide investigators with state-of-the-art support services for their research that would be difficult, if not impossible, to access elsewhere. These include: i) Tissue Culture and Histology Core;ii) Immunophenotyping Core;iii) Advanced Imaging Core;and iv) Administrative Core. These highly interactive Cores provide a solid base on which to launch a powerful presence in cutaneous biology at this institution. A major goal of this SDRC is to nurture the development of innovative ideas from investigators in the broader Columbia community that can ultimately be translated into peer-reviewed funded programs. The Cores and P&F Studies are integrated under the direction of an Administrative Core that provides highly effective and well-organized support to assure maximally efficient integration of the SDRC and its multiple components within Columbia University. A multifaceted Enrichment Program containing a broad spectrum of innovative educational activities is an integral component of this SDRC as is a major commitment to training outstanding medical students, residents, fellows and graduate students with real potential for future leadership in Dermatology a specialty with a need for strengthening its academic base. The CUMCSDRC has established a base of excellence in cutaneous biology and investigative dermatology in the New York region that has the potential to enhance public and professional awareness of the importance of skin diseases and to improve the quality of life of individuals suffering from skin disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
2P30AR044535-10
Application #
8160004
Study Section
Special Emphasis Panel (ZAR1-HL (M1))
Program Officer
Baker, Carl
Project Start
1997-07-20
Project End
2016-06-30
Budget Start
2011-08-01
Budget End
2012-06-30
Support Year
10
Fiscal Year
2011
Total Cost
$643,997
Indirect Cost
Name
Columbia University (N.Y.)
Department
Dermatology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Shen, Yao; Stanislauskas, Milda; Li, Gen et al. (2017) Epigenetic and genetic dissections of UV-induced global gene dysregulation in skin cells through multi-omics analyses. Sci Rep 7:42646
Mathew, Grinu; Hannan, Abdul; Hertzler-Schaefer, Kristina et al. (2016) Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proc Natl Acad Sci U S A 113:13156-13161
Shen, Yao; Kim, Arianna L; Du, Rong et al. (2016) Transcriptome Analysis Identifies the Dysregulation of Ultraviolet Target Genes in Human Skin Cancers. PLoS One 11:e0163054
Dai, Zhenpeng; Xing, Luzhou; Cerise, Jane et al. (2016) CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata. J Immunol 197:1089-99
Abaci, Hasan E; Guo, Zongyou; Coffman, Abigail et al. (2016) Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC-Derived Endothelial Cells. Adv Healthc Mater 5:1800-7
Dainichi, Teruki; Hayden, Matthew S; Park, Sung-Gyoo et al. (2016) PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division. Cell Rep 15:1615-23
Johnson, Dylan; Mathur, Mohit C; Kobayashi, Tomoyoshi et al. (2016) The Cardiomyopathy Mutation, R146G Troponin I, Stabilizes the Intermediate ""C"" State of Regulated Actin under High- and Low-Free Ca(2+) Conditions. Biochemistry 55:4533-40
Shinkuma, Satoru; Guo, Zongyou; Christiano, Angela M (2016) Site-specific genome editing for correction of induced pluripotent stem cells derived from dominant dystrophic epidermolysis bullosa. Proc Natl Acad Sci U S A 113:5676-81
Kim, Arianna L; Back, Jung Ho; Zhu, Yucui et al. (2016) AKT1 Activation is Obligatory for Spontaneous BCC Tumor Growth in a Murine Model that Mimics Some Features of Basal Cell Nevus Syndrome. Cancer Prev Res (Phila) 9:794-802
Sun, Xiaoyun; Kim, Arianna; Nakatani, Masashi et al. (2016) Distinctive molecular responses to ultraviolet radiation between keratinocytes and melanocytes. Exp Dermatol 25:708-13

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