The Bone Center Microarray Core Facility will provide Bone Center investigators with high quality human, rat and mouse cDNA microarrays and technical expertise to broadly define and compare gene expression patterns. The Bone Center Microarray Core Facility will leverage significant support from the University of Michigan Microarray Network. The University of Michigan Microarray Network represents a commitment of greater than $2 million. This Network provides funds for equipment, acts as clearinghouse for technologic advancement, and purchases all commercially available sequence-verified human, rat and mouse clones; these clones will be duplicated and distributed to the Bone Center Microarray Core Facility free of charge. The Bone Center Microarray Core Facility will be housed in the existing Mental Health Research Institute/Department of Psychiatry (MHRI/Psych) Microarray Node. The Bone Center Microarray Core Facility will contribute one full time research assistant to the existing MHRI/Psych Microarray Node and will pay all costs associated with microarray production and analysis by Bone Center investigators. No support is being requested for equipment as all needed equipment is currently in place within the fully operational MHRI/Psych Microarray Node. The Bone Microarray Core Facility will be Co-Directed by Drs. Ignelzi and Thompson. Dr. Ignelzi, an experienced investigator in the bone field, will help Bone Center investigators design their experiments to fully utilize the potential of microarray technologies and he will assist investigators analyze their data. Dr. Thompson will run the Bone Center Microarray Core Facility on a day to day basis. Dr. Thompson has substantial microarray expertise and has established a fully functional microarray laboratory (MHRI/Psych Microarray Node) as well as the Central Node within the University of Michigan Microarray Network. In conjunction with the Bone Cell Molecular and Functional Analysis Core, the Bone Center Microarray Core Facility will provide a full range of microarray services to Bone Center investigators. This user-friendly core facility will advance scientific progress in many areas related to bone structure, maintenance and function.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
1P30AR046024-01A1
Application #
6458246
Study Section
Special Emphasis Panel (ZAR1)
Project Start
2001-05-15
Project End
2006-04-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Decker, A M; Jung, Y; Cackowski, F et al. (2016) The role of hematopoietic stem cell niche in prostate cancer bone metastasis. J Bone Oncol 5:117-120
Zalucha, J L; Jung, Y; Joseph, J et al. (2015) The Role of Osteoclasts in Early Dissemination of Prostate Cancer Tumor Cells. J Cancer Stem Cell Res 3:
Shiozawa, Yusuke; Taichman, Russell S (2015) Bone: Elucidating which cell erythropoietin targets in bone. Nat Rev Endocrinol 11:263-4
Jung, Younghun; Wang, Jingcheng; Lee, Eunsohl et al. (2015) Annexin 2-CXCL12 interactions regulate metastatic cell targeting and growth in the bone marrow. Mol Cancer Res 13:197-207
Cordeiro-Spinetti, Eric; Taichman, Russell S; Balduino, Alex (2015) The bone marrow endosteal niche: how far from the surface? J Cell Biochem 116:6-11
Yumoto, Kenji; Berry, Janice E; Taichman, Russell S et al. (2014) A novel method for monitoring tumor proliferation in vivo using fluorescent dye DiD. Cytometry A 85:548-55
Yumoto, Kenji; Eber, Matthew R; Berry, Janice E et al. (2014) Molecular pathways: niches in metastatic dormancy. Clin Cancer Res 20:3384-9
Yang, Kimberline R; Mooney, Steven M; Zarif, Jelani C et al. (2014) Niche inheritance: a cooperative pathway to enhance cancer cell fitness through ecosystem engineering. J Cell Biochem 115:1478-85
Meganck, J A; Begun, D L; McElderry, J D et al. (2013) Fracture healing with alendronate treatment in the Brtl/+ mouse model of osteogenesis imperfecta. Bone 56:204-12
Shiozawa, Yusuke; Nie, Biao; Pienta, Kenneth J et al. (2013) Cancer stem cells and their role in metastasis. Pharmacol Ther 138:285-93

Showing the most recent 10 out of 82 publications