This is a Competitive renewal application for the P30-supported Cincinnati Rheumatic Diseases Core Center (CRDCC). The overall goal of the CRDCC is to promote biomedical research that yields insights into fundamental processes and pathogenic mechanisms of rheumatic diseases in children, which can lead to innovative treatments for these diseases.
The aims of the CRDCC are to foster this research and promote interdivisional and interdepartmental collaborations, with a focus on translational opportunities. CRDCC-supported projects have great potential to advance the national research agenda related to rheumatic diseases, and represent an area of tremendous strength and resource investment at Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine. The CRDCC offers four innovative research cores, including Pediatric Rheumatology Tissue Repository Core, Animal Models Core, Integrative Cell Phenotyping and Morphology Core, and Bioinformatics Core. Collectively, these Cores form a powerful infrastructure that fosters development of personalized and predictive medical approaches based on genomics and disease mechanisms. The CRDCC supports disease based research across the continuum of discovery, where laboratory findings generate translational studies that lead to clinical trials. In addition to advancing knowledge of pediatric rheumatic disease, the goals of the CRDCC include recruitment of established investigators to bring new expertise to the field, cultivation of collaborations among Research Base investigators, and encouragement of young investigators committed to pursuing research careers focused on pediatric rheumatic disease. These goals of the CRDCC are particularly supported by a Pilot &Feasibility Study Program that will transcend the Cincinnati Research Base to include pediatric rheumatology investigators across the US. The CRDCC also will improve the Cincinnati Research Base through an enrichment program of local seminars, workshops and symposia. The success of the CRDCC is evidenced by productivity of the Research Base, the extensive scope of ongoing collaborations, and the Research Base's record of receiving funding for cutting edge research related to pediatric rheumatic disease. These past accomplishments are likely to be strongly predictive of the future success of CRDCC-supported research.

Public Health Relevance

The Cincinnati Rheumatic Diseases Core Center will promote biomedical research that yields insights into fundamental processes and pathogenic mechanisms of rheumatic diseases in children. This will be done by coordinating research core services and promoting interdivisional and interdepartmental collaborations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR047363-13
Application #
8500199
Study Section
Special Emphasis Panel (ZAR1-MLB (M1))
Program Officer
Wang, Yan Z
Project Start
2001-03-15
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
13
Fiscal Year
2013
Total Cost
$568,842
Indirect Cost
$197,050
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Rydyznski, Carolyn E; Cranert, Stacey A; Zhou, Julian Q et al. (2018) Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers. Cell Rep 24:3367-3373.e4
Carroll, Kaitlin R; Elfers, Eileen E; Stevens, Joseph J et al. (2018) Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells. Diabetes 67:2319-2328
Goodman, Michael Aaron; Arumugam, Paritha; Pillis, Devin Marie et al. (2018) Foamy Virus Vector Carries a Strong Insulator in Its Long Terminal Repeat Which Reduces Its Genotoxic Potential. J Virol 92:
Hinks, Anne; Marion, Miranda C; Cobb, Joanna et al. (2018) Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis. Arthritis Rheumatol 70:957-962
Gupta, Varsha; Tangpricha, Vin; Yow, Eric et al. (2018) Analysis of relationships between 25-hydroxyvitamin D, parathyroid hormone and cathelicidin with inflammation and cardiovascular risk in subjects with paediatric systemic lupus erythematosus: an Atherosclerosis Prevention in Paediatric Lupus Erythematosus Lupus Sci Med 5:e000255
Rochman, Yrina; Dienger-Stambaugh, Krista; Richgels, Phoebe K et al. (2018) TSLP signaling in CD4+ T cells programs a pathogenic T helper 2 cell state. Sci Signal 11:
Rueda, Cesar M; Rodríguez-Perea, Ana Lucia; Moreno-Fernandez, Maria et al. (2017) High density lipoproteins selectively promote the survival of human regulatory T cells. J Lipid Res 58:1514-1523
Forsberg, Matthew H; Ciecko, Ashley E; Bednar, Kyle J et al. (2017) CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice. J Immunol 198:3857-3868
Moncrieffe, Halima; Bennett, Mark F; Tsoras, Monica et al. (2017) Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate. Rheumatology (Oxford) 56:1542-1551
Bertaux-Skeirik, Nina; Wunderlich, Mark; Teal, Emma et al. (2017) CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. J Pathol 242:463-475

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