The purpose of the Microarray Core is to assist Rheumatic Diseases Core Center scientists in the use ofhigh-throughput gene expression profiling methods towards the solution of problems in the biology ofrheumatic diseases. The Rheumatic Diseases Core Center Microarray Core comprises a separatecomponent within the existing Affymetrix and cDNA Micorarray Core, which also serves investigatorsaffiliated with the University of Michgan Comprehensive Cancer Center and all medical school investigators.The Director of this combined Core is Dr. Jill A. Macoska, Associate Professor in the Department of Urologyin the University of Michigan School of Medicine, who has served as the Core Director since 2000. The Coreexists to assist investigators with the design, conduct and analysis of gene expression profiling experimentsusing oligonucleotide- and cDNA-based microarray technology and quantitative polymerase chain reactiontechnology. The Core also offers tools for genomics studies, including a SNP haplotyping service andAffymetrix HuSNP GeneChip services.
The Specific Aims of the Core are: 1. Assist investigators with experimental design and implementation. 2. Provide probe preparation, labeling, hybridization, washing, and data acquisition for microarray and GeneChip experiments. 3. Assist investigators with quantitative PCR studies and SNP genotyping experiments. 4. Provide statistical and bioinformatics support. 5. Provide training for lab personnel to perform experimental techniques used in the Core.
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