The DF/HCC Lymphoma and IVlyeloma Program includes a multidisciplinary group of 66 investigators from seven DF/HCC institutions who work together to explore the causes, define the pathogenetic mechanisms and improve the therapy of lymphoid neoplasms. At the time of the last CCSG renewal the Program received an Excellent to Outstanding merit score. Lymphoma and Myeloma Program members are: 1) experts in many of the most common lymphoid malignancies;2) investigators with lymphoma and myeloma research programs spanning basic, translational and clinical areas;3) dedicated clinical investigators;4) hematopathologists with demonstrated expertise in lymphoid malignancies;and 5) biostatisticians who specialize in these diseases. DF/HCC provides a mechanism for these lymphoma/myeloma investigators to have a cohesive program of basic and clinical investigation based upon complementary and synergistic areas of expertise. Program investigators received over $12.7 million peer-reviewed support in 2009, of which $7.5 million was from NCI funding. They also published 691 papers (33% intra-programmatic, 48% inter-programmatic and 37% inter-institutional) in the current funding period (2006 to 2010). The Lymphoma and Myeloma Program has the following specific objectives: 1) elucidate pathogenetic mechanisms underiying specific lymphoid neoplasms;2) develop novel therapeutic approaches to lymphoid malignancies;and 3) evaluate treatment outcomes and long-term complications in lymphoma and myeloma patients..
The Lymphoma and Myeloma Program is committed to characterizing specific lymphoid malignancies at both a cellular and molecular level using state-of-the-art approaches including informative in vivo models and comprehensive analysis of molecular signatures. In addition to gaining basic insights into pathogenetic mechanisms and predispo treatment targets.
| Santana-Codina, Naiara; Roeth, Anjali A; Zhang, Yi et al. (2018) Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis. Nat Commun 9:4945 |
| Cox, Andrew G; Tsomides, Allison; Yimlamai, Dean et al. (2018) Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. EMBO J 37: |
| Oxnard, Geoffrey R; Hu, Yuebi; Mileham, Kathryn F et al. (2018) Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T790M-Positive Lung Cancer and Acquired Resistance to Osimertinib. JAMA Oncol 4:1527-1534 |
| Patil, Prasad; Parmigiani, Giovanni (2018) Training replicable predictors in multiple studies. Proc Natl Acad Sci U S A 115:2578-2583 |
| Agoston, Agoston T; Pham, Thai H; Odze, Robert D et al. (2018) Columnar-Lined Esophagus Develops via Wound Repair in a Surgical Model of Reflux Esophagitis. Cell Mol Gastroenterol Hepatol 6:389-404 |
| Barber, Lauren; Gerke, Travis; Markt, Sarah C et al. (2018) Family History of Breast or Prostate Cancer and Prostate Cancer Risk. Clin Cancer Res 24:5910-5917 |
| Kwee, Brian J; Budina, Erica; Najibi, Alexander J et al. (2018) CD4 T-cells regulate angiogenesis and myogenesis. Biomaterials 178:109-121 |
| Madsen, Thomas; Braun, Danielle; Peng, Gang et al. (2018) Efficient computation of the joint probability of multiple inherited risk alleles from pedigree data. Genet Epidemiol 42:528-538 |
| Chen, Jingjing; Guccini, Ilaria; Di Mitri, Diletta et al. (2018) Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet 50:219-228 |
| Li, Andrew G; Murphy, Elizabeth C; Culhane, Aedin C et al. (2018) BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1? activation. Proc Natl Acad Sci U S A 115:E9600-E9609 |
Showing the most recent 10 out of 411 publications
