Abstract

The Biostatistics Core provides statistical expertise for the planning, conduct, analysis and reporting of clinical trials, epidemiologic and population-based studies, studies in genetic susceptibility of cancer and experiments in basic research in the biology of cancer. This includes consultation on all clinical protocols, and education for all DF/HCC members in the areas of study design, data collection, computerization and statistical methods. The facility also plays a key role in the PRMS and DSM processes of the Center. The Core ensures that experimental designs, study monitoring and data analyses take advantage of robust and efficient methods that reflect best practices in biostatistics and epidemiology, and that DF/HCC members receive support when planning new applications. The facility has been continuously funded by CCSG mechanisms for the past decade. Director: Paul Catalano, ScD (DFCI) Category: 6.01 (Biostatistics) IVlanagement: Joint (Cancer Center and Institutional)

Public Health Relevance

The Biostatistics Core provides statistical expertise for the planning, conduct, analysis and reporting of clinical trials, epidemiologic and population-based studies, studies in genetic susceptibility of cancer and experiments in basic research in the biology of cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
4P30CA006516-51
Application #
8975652
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
2017-11-30
Budget Start
2015-12-01
Budget End
2016-11-30
Support Year
51
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Chen, Jingjing; Guccini, Ilaria; Di Mitri, Diletta et al. (2018) Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet 50:219-228
Li, Andrew G; Murphy, Elizabeth C; Culhane, Aedin C et al. (2018) BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1? activation. Proc Natl Acad Sci U S A 115:E9600-E9609
McBrayer, Samuel K; Mayers, Jared R; DiNatale, Gabriel J et al. (2018) Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell 175:101-116.e25
Stopsack, Konrad H; Gonzalez-Feliciano, Amparo G; Peisch, Samuel F et al. (2018) A Prospective Study of Aspirin Use and Prostate Cancer Risk by TMPRSS2:ERG Status. Cancer Epidemiol Biomarkers Prev 27:1231-1233
Kamareddine, Layla; Wong, Adam C N; Vanhove, Audrey S et al. (2018) Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host. Nat Microbiol 3:243-252
Schilit, Samantha L P; Morton, Cynthia C (2018) 3C-PCR: a novel proximity ligation-based approach to phase chromosomal rearrangement breakpoints with distal allelic variants. Hum Genet 137:55-62
Sievers, Quinlan L; Gasser, Jessica A; Cowley, Glenn S et al. (2018) Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity. Blood 132:1293-1303
Kelley, Katherine A; Wieghard, Nicole; Chin, Yuki et al. (2018) MiR-486-5p Downregulation Marks an Early Event in Colorectal Carcinogenesis. Dis Colon Rectum 61:1290-1296
Yao, Lina; Seaton, Sarah Craven; Ndousse-Fetter, Sula et al. (2018) A selective gut bacterial bile salt hydrolase alters host metabolism. Elife 7:
Jalbut, Marla M; Brunner, Andrew M; Amrein, Philip C et al. (2018) Early infectious complications among patients treated with induction compared to hypomethylating therapy for acute myeloid leukemia. Leuk Lymphoma 59:988-991

Showing the most recent 10 out of 411 publications