The mission of the McArdle Laboratory Cancer center is to pursue research directed toward understanding the cause and biology of cancer and the factors the regulate normal and neoplastic growth and differentiation and to train graduate and postdoctoral students in basic cancer research. The investigators at the McArdle Laboratory focus their efforts in three program areas. The goal of the program on the Molecular Biology and Genetics of Tumor Viruses is to understand the life cycles of five families of viruses that cause human cancer and the biological effects that these viruses have on their infected host cells. Five faculty use molecular biology and genetics to elucidate mechanisms of viral replication, the regulation of viral gene expression, and the oncogenic properties of viral gene products. In the program on the Biochemistry and Genetics of Chemical Carcinogenesis, seven faculty seek to elucidate the basic biochemical, and molecular genetic approaches are used to understand the underlying events involved in the initiation, promotion, and progression of carcinogenesis. The objective of the program on the Biology and Genetics of Cell Growth Control is to identify factors and processes that control cell replication and differentiation in normal and neoplastic cells. The eight faculty in the program pursue biochemical and genetic approaches to understanding the regulation of growth-related genes at the transcriptional and post-transcriptional levels and in vivo genetic approaches to the identification of novel genes that play a role in cancer risk of pathogenesis. All of the faculty are committed to research training at the pre-and postdoctoral levels. Currently, 53 graduate students and 35 postdoctoral fellows are receiving training in basic cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA007175-34
Application #
2601177
Study Section
Subcommittee G - Education (NCI)
Program Officer
Mccormick, Patricia
Project Start
1978-09-01
Project End
2001-03-31
Budget Start
1998-05-22
Budget End
1999-03-31
Support Year
34
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Thompson, Nancy E; Glaser, Bryan T; Foley, Katherine M et al. (2009) Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB. J Biol Chem 284:24754-66
Habig, Jeffrey W; Loeb, Daniel D (2006) Sequence identity of the direct repeats, DR1 and DR2, contributes to the discrimination between primer translocation and in situ priming during replication of the duck hepatitis B virus. J Mol Biol 364:32-43
Liu, Ning; Ji, Lin; Maguire, Megan L et al. (2004) cis-Acting sequences that contribute to the synthesis of relaxed-circular DNA of human hepatitis B virus. J Virol 78:642-9
Tessier, Charles R; Doyle, Glenn A; Clark, Brad A et al. (2004) Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Cancer Res 64:209-14
Ostrow, Kristin M; Loeb, Daniel D (2004) Underrepresentation of the 3' region of the capsid pregenomic RNA of duck hepatitis B virus. J Virol 78:2179-86
Habig, Jeffrey W; Loeb, Daniel D (2003) Template switches during plus-strand DNA synthesis of duck hepatitis B virus are influenced by the base composition of the minus-strand terminal redundancy. J Virol 77:12412-20
Habig, Jeffrey W; Loeb, Daniel D (2003) The conformation of the 3' end of the minus-strand DNA makes multiple contributions to template switches during plus-strand DNA synthesis of duck hepatitis B virus. J Virol 77:12401-11
Bunger, Maureen K; Moran, Susan M; Glover, Edward et al. (2003) Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem 278:17767-74
Liu, Ning; Tian, Ru; Loeb, Daniel D (2003) Base pairing among three cis-acting sequences contributes to template switching during hepadnavirus reverse transcription. Proc Natl Acad Sci U S A 100:1984-9
Mueller-Hill, Karlyn; Loeb, Daniel D (2002) cis-Acting sequences 5E, M, and 3E interact to contribute to primer translocation and circularization during reverse transcription of avian hepadnavirus DNA. J Virol 76:4260-6

Showing the most recent 10 out of 79 publications