Abstract

The Monoclonal Antibody Core Facility (MACF) provides the following four high quality services not onlyat a reasonable cost to investigators but also in a timely manner.1. The generation of new MAbs / hybridomas to a specific antigen of interest.2. MAb production (in vitro), purification and modification (including conjugation to fluorphores,biotion and enzymes and the fragmentation of MAbs).3. Mycoplasma testing of tissue culture samples.4. In vitro production of recombinant/secreted proteins.Monoclonal antibodies (MAbs) are essential tools used in most if not all fields of biomedical research, in thediagnosis of diseases, and in the treatment of diseases such as infections and cancer. The goal of theMACF is to support the research interests of MSKCC investigators by providing key services related to theproduction, purification and use of MAbs.Over the last 5 years demand for the MACF services has remained consistently high. From July 2005through July 2006, 61 investigators from 9 out of 10 programs placed orders with the facility for anycombination of the services noted above.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA008748-43
Application #
7671820
Study Section
Subcommittee G - Education (NCI)
Project Start
2008-07-31
Project End
2012-12-31
Budget Start
2008-07-31
Budget End
2008-12-31
Support Year
43
Fiscal Year
2008
Total Cost
$164,877
Indirect Cost

  Institution

Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Davis, Mellar P; Pasternak, Gavril; Behm, Bertrand (2018) Treating Chronic Pain: An Overview of Clinical Studies Centered on the Buprenorphine Option. Drugs 78:1211-1228
Suzawa, Ken; Offin, Michael; Lu, Daniel et al. (2018) Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14-mutant Non-small Cell Lung Cancer. Clin Cancer Res :
Horvat, Joao V; Durando, Manuela; Milans, Soledad et al. (2018) Apparent diffusion coefficient mapping using diffusion-weighted MRI: impact of background parenchymal enhancement, amount of fibroglandular tissue and menopausal status on breast cancer diagnosis. Eur Radiol 28:2516-2524
Al Efishat, Mohammad A; Attiyeh, Marc A; Eaton, Anne A et al. (2018) Multi-institutional Validation Study of Pancreatic Cyst Fluid Protein Analysis for Prediction of High-risk Intraductal Papillary Mucinous Neoplasms of the Pancreas. Ann Surg 268:340-347
Dickson, Brendan C; Sung, Yun-Shao; Rosenblum, Marc K et al. (2018) NUTM1 Gene Fusions Characterize a Subset of Undifferentiated Soft Tissue and Visceral Tumors. Am J Surg Pathol 42:636-645
Gao, Yiming; Quinn, Brian; Pandit-Taskar, Neeta et al. (2018) Patient-specific organ and effective dose estimates in pediatric oncology computed tomography. Phys Med 45:146-155
Yang, Lin; Alyasova, Anna; Ye, Dingwei et al. (2018) RECORD-4 multicenter phase 2 trial of second-line everolimus in patients with metastatic renal cell carcinoma: Asian versus non-Asian population subanalysis. BMC Cancer 18:195
Majumdar, Susruta; Devi, Lakshmi A (2018) Strategy for making safer opioids bolstered. Nature 553:286-288
Freites-Martinez, Azael; Shapiro, Jerry; van den Hurk, Corina et al. (2018) CME Part 2: Hair disorders in cancer survivors Persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, and hair growth disorders related to endocrine therapy or cancer surgery. J Am Acad Dermatol :
Barbetta, Arianna; Nobel, Tamar B; Sihag, Smita et al. (2018) Neutrophil to Lymphocyte Ratio as Predictor of Treatment Response in Esophageal Squamous Cell Cancer. Ann Thorac Surg 106:864-871

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