Abstract

The mission of the Gene Transfer and Somatic Cell Engineering (GTSC) Core is to develop, validate, and supply cell-based experimental products for Phase I and II clinical trials so that investigators can evaluate their safety and potential clinical benefit. In 2014, the GTSC Core moved to the Cell Therapy and Cell Engineering Facility (CTCEF), which opened when the Zuckerman II building was opened.
The aims of the GTSC Core have not changed. The Core supports the implementation of Phase I/II clinical trials based on cell engineering and adoptive cell therapies.
Its aims are as follows:
AIM1 : To develop SOPs and batch records for cell processing and engineering, vector production.
AIM2 : GMP manufacturing: Patient cell (expansion, purification, transduction, formulation); Vector stocks (plasmid DNA, cell banks).
AIM3 : Biosafety/release testing: Patient cells and vector stocks (e.g., phenotype, potency, purity, stability); Gene transfer/expression.
AIM4 : To monitor patients? samples post-infusion (e.g., FACS, Q-PCR).
AIM5 : To provide technological and regulatory expertise (GXP, FDA, RAC-NIH).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA008748-55
Application #
10084821
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-01-20
Project End
2023-12-31
Budget Start
2021-01-01
Budget End
2021-12-31
Support Year
55
Fiscal Year
2021
Total Cost
Indirect Cost

  Institution

Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Niethammer, Philipp (2018) Wound redox gradients revisited. Semin Cell Dev Biol 80:13-16
Latte-Naor, Shelly; Sidlow, Robert; Sun, Lingyun et al. (2018) Influence of family on expected benefits of complementary and alternative medicine (CAM) in cancer patients. Support Care Cancer 26:2063-2069
Grenen, Emily; Kent, Erin E; Hennessy, Erin et al. (2018) Association Between Nutrition Resource Stress and Dietary Consumption: Results From a U.S. Nationally Representative Survey. Health Educ Behav 45:524-531
Corrias, Giuseppe; Monti, Serena; Horvat, Natally et al. (2018) Imaging features of malignant abdominal neuroendocrine tumors with rare presentation. Clin Imaging 51:59-64
Hristov, Boris; Eguchi, Takashi; Bains, Sarina et al. (2018) Minimally Invasive Lobectomy Is Associated With Lower Noncancer-specific Mortality in Elderly Patients: A Propensity Score Matched Competing Risks Analysis. Ann Surg :
Jannetti, Stephen A; Carlucci, Giuseppe; Carney, Brandon et al. (2018) PARP-1-Targeted Radiotherapy in Mouse Models of Glioblastoma. J Nucl Med 59:1225-1233
Strong, Vivian E (2018) Progress in gastric cancer. Updates Surg 70:157-159
Haak, Bastiaan W; Littmann, Eric R; Chaubard, Jean-Luc et al. (2018) Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT. Blood 131:2978-2986
Carrera, Cristina; Scope, Alon; Dusza, Stephen W et al. (2018) Clinical and dermoscopic characterization of pediatric and adolescent melanomas: Multicenter study of 52 cases. J Am Acad Dermatol 78:278-288
Hechtman, Jaclyn F; Abou Alfa, Ghassan K; Stadler, Zsofia K et al. (2018) Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA. Hum Pathol :

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