Abstract

The primary goal of the Tumor Tissue Core Laboratory is to facilitate cancer research by supplying tissues (neoplastic and normal) to investigators. We will achieve this goal through these Specific Aims: 1. To maintain a repository of tumors and matched normal tissues from patients with well defined therapies, clinical outcomes and clinical histories, and to provide a Web-based database of available tumor and normal tissues for investigators to examine. 2. To assist investigators with the selection of human tissues for their research projects and help them to develop appropriate protocols for the processing of these tissues. 3. To protect patient welfare by guarding the diagnostic usefulness of specimens, by keeping the identification of patients confidential, and by ensuring that investigators using human tissue have the proper Institutional Review Board (IRB) review. 4. To perform quality-control measures so that tissues and samples provided to investigators are consistent and reliable for research purposes. 5. To collaborate with the Cancer Biomedical Informatics Grid (caBIG?) initiative to link the Tumor Tissue Core Laboratory with other such repositories, nationally.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA012197-33
Application #
7578251
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2008-02-01
Budget End
2009-01-31
Support Year
33
Fiscal Year
2008
Total Cost
$126,085
Indirect Cost

  Institution

Name
Wake Forest University Health Sciences
Department
Type
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157

  Publications

Rimkus, Tadas K; Carpenter, Richard L; Sirkisoon, Sherona et al. (2018) Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44. Cancer Res 78:2589-2600
Bonin, Keith; Smelser, Amanda; Moreno, Naike Salvador et al. (2018) Structured illumination to spatially map chromatin motions. J Biomed Opt 23:1-8
Rogers, LeAnn C; Davis, Ryan R; Said, Naveen et al. (2018) Blocking LPA-dependent signaling increases ovarian cancer cell death in response to chemotherapy. Redox Biol 15:380-386
Maggiore, Ronald J; Callahan, Kathryn E; Tooze, Janet A et al. (2018) Geriatrics fellowship training and the role of geriatricians in older adult cancer care: A survey of geriatrics fellowship directors. Gerontol Geriatr Educ 39:170-182
Melvin, Ryan L; Xiao, Jiajie; Godwin, Ryan C et al. (2018) Visualizing correlated motion with HDBSCAN clustering. Protein Sci 27:62-75
Faig, Jennifer; Haughton, Michael; Taylor, Richard C et al. (2018) Retrospective Analysis of Cisplatin Nephrotoxicity in Patients With Head and Neck Cancer Receiving Outpatient Treatment With Concurrent High-dose Cisplatin and Radiotherapy. Am J Clin Oncol 41:432-440
Nelson, Kimberly J; Perkins, Arden; Van Swearingen, Amanda E D et al. (2018) Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid Redox Signal 28:521-536
Swanner, Jessica; Singh, Ravi (2018) Synthesis, Purification, Characterization, and Imaging of Cy3-Functionalized Fluorescent Silver Nanoparticles in 2D and 3D Tumor Models. Methods Mol Biol 1790:209-218
Holmila, Reetta J; Vance, Stephen A; Chen, Xiaofei et al. (2018) Mitochondria-targeted Probes for Imaging Protein Sulfenylation. Sci Rep 8:6635
Feliz-Mosquea, Yismeilin R; Christensen, Ashley A; Wilson, Adam S et al. (2018) Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy. Breast Cancer Res Treat 172:69-82

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