05 CANCER CHEMOPREVENTION (CCP) PROGRAM ABSTRACT The UAB Cancer Center Chemoprevention Program was established to identify novel chemopreventive agents capable of preventing cancer, to determine the ability of naturally occurring and synthetic chemicals to prevent or delay carcinogenesis, to determine their mechanisms of action and identify biomarkers, and to perform early phase chemoprevention trials evaluating novel chemopreventive agents. The focus of the Program is directed toward synthetic retinoids, non-steroidal anti-inflammatory drugs, and phytochemicals. However, the scope of the program and depth of expertise have been expanded by strategic recruitment and a mentoring program. Furthermore, transdisciplinary research is nurtured through focused working groups. This program is co- directed by Dr. Craig A. Elmets (Professor and Chair, Department of Dermatology and Director of the UAB Skin Diseases Research Center) and Dr. Clinton J. Grubbs (Professor, Department of Surgery and Director of the Chemoprevention Center). Currently, the program is comprised of 18 members from 10 departments and 5 schools. This program has $4,187,741 in annual direct cost funding, of which 76% is derived from the NCI. In addition to the traditional utilization of inter-programmatic teams and intra-programmatic collaborations, the capabilities of the program are greatly expanded by established extramural agreements: (1) Dr. Grubbs directs Task Order from the NCI PREVENT program which awards contracts to investigators both at UAB and other institutions, and (2) Dr. Elmets participates in an NCI-funded consortium of early phase human chemoprevention trials led by the University of Wisconsin. Over the past four years, the program has produced 206 publications, of which 35% % were intra-programmatic, 28%% were inter-programmatic, and 34% were inter-institutional. A vibrant communications component that includes a seminar series with lecturers from inside and outside the University supports collaborative research among program investigators. Major completed studies at UAB have moved chemopreventive agents from various classes (including rexinoids, cyclooxygenase inhibitors, and dietary polyphenols) to clinical trials during the last few years.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA013148-46S3
Application #
9757080
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Belin, Precilla L
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
46
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Jimenez, Rachel V; Wright, Tyler T; Jones, Nicholas R et al. (2018) C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance. Front Immunol 9:372
Engle, Staci E; Antonellis, Patrick J; Whitehouse, Logan S et al. (2018) A CreER mouse to study melanin concentrating hormone signaling in the developing brain. Genesis 56:e23217
Van Arsdale, Anne R; Arend, Rebecca C; Cossio, Maria J et al. (2018) Insulin-like growth factor 2: a poor prognostic biomarker linked to racial disparity in women with uterine carcinosarcoma. Cancer Med 7:616-625
Kim, Harrison (2018) Modification of population based arterial input function to incorporate individual variation. Magn Reson Imaging 45:66-71
Leath 3rd, Charles A; Monk, Bradley J (2018) Twenty-first century cervical cancer management: A historical perspective of the gynecologic oncology group/NRG oncology over the past twenty years. Gynecol Oncol 150:391-397
Park, Misun; Yoon, Young Sup (2018) Cardiac Regeneration with Human Pluripotent Stem Cell-Derived Cardiomyocytes. Korean Circ J 48:974-988
Toboni, Michael D; Smith, Haller J; Bae, Sejong et al. (2018) Predictors of Unplanned Reoperation for Ovarian Cancer Patients From the National Surgical Quality Improvement Program Database. Int J Gynecol Cancer 28:1427-1431
Dionne-Odom, J Nicholas; Applebaum, Allison J; Ornstein, Katherine A et al. (2018) Participation and interest in support services among family caregivers of older adults with cancer. Psychooncology 27:969-976
Demark-Wahnefried, Wendy; Schmitz, Kathryn H; Alfano, Catherine M et al. (2018) Weight management and physical activity throughout the cancer care continuum. CA Cancer J Clin 68:64-89
Bandari, Shyam K; Purushothaman, Anurag; Ramani, Vishnu C et al. (2018) Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior. Matrix Biol 65:104-118

Showing the most recent 10 out of 747 publications