01 INFLAMMATION, IMMUNOLOGY AND IMMUNOTHERAPEUTICS (III) PROGRAM ABSTRACT Decades of research on basic immunology and the interactions of tumors and the immune system have led over the past few years to an explosive increase in the successes of immunotherapeutic modalities in cancer. The objective of the Inflammation, Immunology, and Immunotherapeutics (III) Program is to build on and to accelerate those successes by developing novel therapeutic approaches for the treatment of leukemia/lymphoma and solid tumors, and to understand and exploit the basic biology of the immune system's responses to cancers. The emphasis is on antibody and T-cell mediated therapy in preclinical models and clinical translation studies. The Tumor Immunology Program has been a component of the Cancer Center since its inception and in 2012, it merged with the Virology Program to become the III Program. It is currently led by Casey T. Weaver, M.D. (Pathology), and Donald J. Buchsbaum, Ph.D. (Radiation Oncology), and has 40 primary faculty members from seven departments. The Program has $11,611,410 in annual direct grant support of cancer relevant research including $756,267 from NCI, $9,592,968 from other NIH Institutes, $289,001 from other peer-reviewed awards, and $973,174 in non-peer-reviewed support. The Program has two major areas of emphasis: (1) development of targeted immunotherapy utilizing antibody specificity to deliver apoptotic stimuli, drugs, or radioactive isotopes to tumors in animal models and human cancer; and (2) exploration of basic immunobiology research in the areas of inflammation and T- and B-cell immunology to translate into immunodiagnostic and immunotherapeutic modalities. The Program has major collaborations with the Experimental Therapeutics and Cancer Cell Biology Programs, and HudsonAlpha including individual projects in the Breast Cancer and Pancreatic Cancer SPOREs. During the previous funding period there were 310 total publications, of which 72 (23%) were intra-programmatic, 69 (22%) inter-programmatic, and 161 (52%) inter-institutional. 1

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013148-47
Application #
9674331
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
47
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Leath 3rd, Charles A; Monk, Bradley J (2018) Twenty-first century cervical cancer management: A historical perspective of the gynecologic oncology group/NRG oncology over the past twenty years. Gynecol Oncol 150:391-397
Park, Misun; Yoon, Young Sup (2018) Cardiac Regeneration with Human Pluripotent Stem Cell-Derived Cardiomyocytes. Korean Circ J 48:974-988
Toboni, Michael D; Smith, Haller J; Bae, Sejong et al. (2018) Predictors of Unplanned Reoperation for Ovarian Cancer Patients From the National Surgical Quality Improvement Program Database. Int J Gynecol Cancer 28:1427-1431
Dionne-Odom, J Nicholas; Applebaum, Allison J; Ornstein, Katherine A et al. (2018) Participation and interest in support services among family caregivers of older adults with cancer. Psychooncology 27:969-976
Demark-Wahnefried, Wendy; Schmitz, Kathryn H; Alfano, Catherine M et al. (2018) Weight management and physical activity throughout the cancer care continuum. CA Cancer J Clin 68:64-89
Bandari, Shyam K; Purushothaman, Anurag; Ramani, Vishnu C et al. (2018) Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior. Matrix Biol 65:104-118
Gowda, Pramod S; Wildman, Benjamin J; Trotter, Timothy N et al. (2018) Runx2 Suppression by miR-342 and miR-363 Inhibits Multiple Myeloma Progression. Mol Cancer Res 16:1138-1148
Dix, Daniel B; McDonald, Andrew M; Gordetsky, Jennifer B et al. (2018) How Would MRI-targeted Prostate Biopsy Alter Radiation Therapy Approaches in Treating Prostate Cancer? Urology 122:139-146
Prince, Andrew C; Moore, Lindsay S; Tipirneni, Kiranya E et al. (2018) Evaluation of optical imaging agents in a fluorescence-guided surgical model of head and neck cancer. Surg Oncol 27:225-230
Gangrade, Abhishek; Pathak, Vibha; Augelli-Szafran, Corinne E et al. (2018) Preferential Inhibition of Wnt/?-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer. Int J Mol Sci 19:

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