The Epidemiology Informatics Shared Resource (EISR) provides informatics and database management expertise to AECC investigators in all phases of their epidemiologic research, with a special focus on developing web-based 'Study Management Informatics Systems'(SMIS) designed to assist in implementing study protocols on an operational level for consortium, single center and multi-centered epidemiological studies. These systems implement best practices and provide automated operational and quality assurance systems which ensure that the studies are conducted appropriately. The facility continually develops new informatics approaches based on emerging standards to enhance scientific research needs and initiates data extraction and data sharing research collaboration portals which maximize the potential for collaboration between investigators. Currently the EISR is managing the data and informatics needs for 63 research projects, of which 42 projects are for AECC members, and serves as a data coordinating center for multi-site studies. The facility provides extensive data management and analyses services, assists faculty in the development of pilot studies, works closely with senior biostatisticians in the production of complex databases and data integration from a multitude of sources, and participates in publications. The EISR has set up and maintains a sophisticated applications framework and integrated data systems infrastructure with data governance and security protocols that are in compliance with evolving standards established by the scientific community, and provide interoperability with other informatics-based systems. The EISR also offers comprehensive Study /Project Management Services to assist in the management of all aspects of research projects, and has extensive experience providing operations management to large-scale studies. Throughout the life-cycle of each project, the EISR personnel provide oversight, and training to study coordinators.

Public Health Relevance

The Epidemiology Informatics Shared Resource provides informatics and database management expertise to investigators in all phases of epidemiologic research, supporting the research mission and goals of the Albert Einstein Cancer Center (AECC). As an NCI-designated Cancer Center, AECC contributes to the national effort to reduce the morbidity and mortality from cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA013330-40
Application #
8582092
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-06-01
Project End
2018-06-30
Budget Start
2013-08-23
Budget End
2014-06-30
Support Year
40
Fiscal Year
2013
Total Cost
$173,895
Indirect Cost
$51,766
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Tiwari, Sangeeta; van Tonder, Andries J; Vilchèze, Catherine et al. (2018) Arginine-deprivation-induced oxidative damage sterilizes Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 115:9779-9784
Celestrin, Kevin; Díaz-Balzac, Carlos A; Tang, Leo T H et al. (2018) Four specific immunoglobulin domains in UNC-52/Perlecan function with NID-1/Nidogen during dendrite morphogenesis in Caenorhabditis elegans. Development 145:
Haider, Afreen; Wei, Yu-Chen; Lim, Koini et al. (2018) PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress. Dev Cell 45:481-495.e8
Cai, Ying; Lin, Jhih-Rong; Zhang, Quanwei et al. (2018) Epigenetic alterations to Polycomb targets precede malignant transition in a mouse model of breast cancer. Sci Rep 8:5535
Li, Ke; Baker, Nicholas E (2018) Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners. Elife 7:
Xie, Xianhong; Xue, Xiaonan; Strickler, Howard D (2018) Generalized linear mixed model for binary outcomes when covariates are subject to measurement errors and detection limits. Stat Med 37:119-136
Carvajal, Luis A; Neriah, Daniela Ben; Senecal, Adrien et al. (2018) Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med 10:
Boku, S; Izumi, T; Abe, S et al. (2018) Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis. Mol Psychiatry 23:985-992
Mendez-Dorantes, Carlos; Bhargava, Ragini; Stark, Jeremy M (2018) Repeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements. Genes Dev 32:524-536
Kushnir, Alexander; Santulli, Gaetano; Reiken, Steven R et al. (2018) Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure. Circulation 138:1144-1154

Showing the most recent 10 out of 1508 publications