- CANCER EPIDEMIOLOGY, PREVENTION AND CONTROL (CEPaC) The CEPaC program plays a central role in the scientific, clinical and public health mission of AECC, and is the focal point for the translation of laboratory-based research into studies at the population level. The broad aims of CEPaC are to conduct studies in human populations to determine the behavioral, environmental and molecular etiologic risk factors that underlie cancer development and outcomes, (especially actionable targets for screening, prevention, and treatment), and further, to implement interventions and test their effectiveness in the community. CEPaC has long been recognized for its contributions to the study of HPV and to molecular epidemiologic cancer research. However, in recent years, cancer prevention and control research has greatly expanded, with a strong focus on the largely poor and minority Bronx population. CEPaC is organized into four major themes: (i) Infectious Risk Factors, including oncogenic HPV, HIV, HCV, and the human microbiome; (ii) Hormonal, Obesity, and Inflammation-Related Risk Factors; (iii) Genetic/Epigenetic Risk Factors; and (iv) Cancer Prevention, Control, and Implementation Science, encompassing prevention, health care delivery, health disparities, survivorship and outcomes, especially in the local catchment area. CEPaC research has also been impactful on clinical guidelines and practice, and recent studies will maintain this trend. For example: (i) CEPaC laboratory advancements led to the characterization of HPV sub-lineages and HPV DNA methylation, both sufficiently associated with strong risk of cervical cancer and precancer with the potential to improve the positive predictive value (PPV) of recently FDA-approved ?primary HPV screening?; (ii) obese women with normal insulin levels were shown to have no greater risk of incident post-menopausal breast cancer than normal weight women with normal insulin, but those with elevated insulin had significantly increased risk regardless of obesity status ? results that demonstrate the importance of etiologic biomarkers in risk stratification (e.g., versus obesity), characterizing possible carcinogenic pathways, and as targets for chemoprevention; (iii) a novel signature of metastatic risk based on laboratory and animal model studies was strongly associated with metastasis of ER+/HER2- tumors in postmenopausal women, and may have a role in guiding treatment decisions; (iv) firefighters who worked at the 9/11 WTC disaster site were found to be at increased risk of developing MUGUS, a precursor of multiple myeloma, leading to changes in monitoring practices in this group. Finally, the recent Einstein/Montefiore merger has increased shared interest in collaborative cancer prevention initiatives in the Bronx, including community needs assessment, defining cancer-health priorities, community outreach, and studies of the impact of these initiatives. There are 30 program members from 14 departments. Current NCI funding is 7.7M (direct); total peer-reviewed funding is 10.9M (direct). There have been 811 publications since July 2013 of which 31% represent intra-programmatic, 14% inter-programmatic, and 62% represent collaborations with investigators at other institutions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013330-48
Application #
9998889
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-06-01
Project End
2022-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
48
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
081266487
City
Bronx
State
NY
Country
United States
Zip Code
10461
Bines, Jose; Tevaarwerk, Amye J (2018) Baby steps: Pregnancy outcomes after human epidermal growth factor receptor 2-targeted therapy. Cancer :
Mathew, Deepti; Wang, Yanhua; Van Arsdale, Anne et al. (2018) Expression of ?V-Tubulin in Secretory Cells of the Fallopian Tube Epithelium Marks Cellular Atypia. Int J Gynecol Cancer 28:363-370
Entenberg, David; Voiculescu, Sonia; Guo, Peng et al. (2018) A permanent window for the murine lung enables high-resolution imaging of cancer metastasis. Nat Methods 15:73-80
Mao, Kai; Quipildor, Gabriela Farias; Tabrizian, Tahmineh et al. (2018) Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun 9:2394
Sharma, Yogeshwar; Liu, Jinghua; Kristian, Kathleen E et al. (2018) In Atp7b-/- Mice Modeling Wilson's Disease Liver Repopulation with Bone Marrowderived Myofibroblasts or Inflammatory Cells and not Hepatocytes is Deleterious. Gene Expr :
Iqbal, Niloy Jafar; Lu, Zhonglei; Liu, Shun Mei et al. (2018) Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity. JCI Insight 3:
Norwood Toro, Laura E; Wang, Yarong; Condeelis, John S et al. (2018) Myosin-IIA heavy chain phosphorylation on S1943 regulates tumor metastasis. Exp Cell Res 370:273-282
De Martino, Daniela; Yilmaz, Emrullah; Orlacchio, Arturo et al. (2018) PI3K blockage synergizes with PLK1 inhibition preventing endoreduplication and enhancing apoptosis in anaplastic thyroid cancer. Cancer Lett 439:56-65
Bhargava, Ragini; Sandhu, Manbir; Muk, Sanychen et al. (2018) C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains. Nat Commun 9:2484
Agalliu, Ilir; Chen, Zigui; Wang, Tao et al. (2018) Oral Alpha, Beta, and Gamma HPV Types and Risk of Incident Esophageal Cancer. Cancer Epidemiol Biomarkers Prev 27:1168-1175

Showing the most recent 10 out of 1508 publications