The Center for Radiological Research offers a comprehensive irradiation service for members of the Cancer Center. This Radiation Laboratory Research Facility is a source of x-rays, gamma-rays and magnetic fields. Anything from macromolecules to small animals can be accommodate, with a large range of doses and dose-rates. The irradiation devices are used in such broad ranging studies as irradiating mice prior to injection with cells, irradiating cells to create feeder layers. creating multiple double strand breaks in the chromosomes of cells prior to radiation fusions, producing radiation transformed cell lines, as well as other applications. The Facility is made up of five irradiation devices; a Siemans X-ray Therapy Unit with operating energies up to 300 keV, an Atomic Energy of Canada Cesium Unit with dose rate of 1Gy/min, a Gamma cell-220 irradiator, which produces a dose rate of 180Gy/min, and two magnetic field exposure systems. The operators of the Facility provide users with safe and efficient operation guidance as well as consultation on dosimetry.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA013696-28S1
Application #
6336324
Study Section
Project Start
2000-07-01
Project End
2001-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
28
Fiscal Year
2000
Total Cost
$296,752
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Jauregui, Ruben; Park, Karen Sophia; Duong, Jimmy K et al. (2018) Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography. Sci Rep 8:13130
O'Neil, Daniel S; Prigerson, Holly G; Mmoledi, Keletso et al. (2018) Informal Caregiver Challenges for Advanced Cancer Patients During End-of-Life Care in Johannesburg, South Africa and Distinctions Based on Place of Death. J Pain Symptom Manage 56:98-106
Liu, Katherine Y; Sengillo, Jesse D; Velez, Gabriel et al. (2018) Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity. Orphanet J Rare Dis 13:138
Koch, Susanne F; Tsang, Stephen H (2018) Success of Gene Therapy in Late-Stage Treatment. Adv Exp Med Biol 1074:101-107
DiCarlo, James E; Mahajan, Vinit B; Tsang, Stephen H (2018) Gene therapy and genome surgery in the retina. J Clin Invest 128:2177-2188
Wert, Katherine J; Velez, Gabriel; Cross, Madeline R et al. (2018) Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface. Free Radic Biol Med 124:408-419
Lee, Andreia; CingĂ–z, Oya; Sabo, Yosef et al. (2018) Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus. Virology 516:165-175
Schrank, Benjamin R; Aparicio, Tomas; Li, Yinyin et al. (2018) Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature 559:61-66
Proto, Jonathan D; Doran, Amanda C; Gusarova, Galina et al. (2018) Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity 49:666-677.e6
Hernandez, Celine; Huebener, Peter; Pradere, Jean-Philippe et al. (2018) HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis. J Clin Invest 128:2436-2451

Showing the most recent 10 out of 331 publications