The long-term goals of the Cancer Epidemiology (CE) Program are to investigate environmental, lifestyle and genetic factors that lead to increased incidence, morbidity and mortality from cancer and to integrate biomarkers into these studies. To achieve this end, the following Specific Goals will be pursued: 1. Carry out molecular epidemiology studies that broadly include the integration of data collected from biospecimens with epidemiologic data to understand cancer risk. These studies will take advantage of almost 20 cohorts actively being studied, many with biospecimens, and the long history of research in the CE Program using biomarkers. 2. Investigate how exposures in key susceptible time periods alter cancer susceptibility. Lifecourse epidemiology and timing of events will be used to capture risk factor data from pre and postnatal periods. 3. Conduct epidemiologic studies around the globe. Longitudinal research is being carried out in Latin America, Asia, Eastern and Western Europe and the Middle East. The CE Program consists of 15 members (all full members) from 3 departments within the School of Public Health and 2 departments within the College of Physicians &Surgeons at Columbia University. The Program is supported by several large Federally-funded collaborative grants including the Breast Cancer Family Registry, the NIEHS Center for Environmental Health in Northern Manhattan and a Superfund Basic Research Program. For the last budget year of the grant (July 1, 2006 - June 30, 2007), the CE Program successfully obtained a total of $6.8M (direct costs) in cancer-relevant grant support, including $2.3M (direct costs) in NCI funding, $4.1 M (direct costs) in other cancer-related peer-reviewed funding, and $0.4M (direct costs) in cancer-related non-peer-reviewed funding. The total number of publications since the previous submission (i.e., 2003-present) was 181 of which 42% were intra-programmatic and 36% inter-programmatic.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013696-37
Application #
8114074
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
37
Fiscal Year
2010
Total Cost
$62,385
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Proto, Jonathan D; Doran, Amanda C; Gusarova, Galina et al. (2018) Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity 49:666-677.e6
Hernandez, Celine; Huebener, Peter; Pradere, Jean-Philippe et al. (2018) HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis. J Clin Invest 128:2436-2451
Lee, Younghyun; Pujol Canadell, Monica; Shuryak, Igor et al. (2018) Candidate protein markers for radiation biodosimetry in the hematopoietically humanized mouse model. Sci Rep 8:13557
Kraakman, Michael J; Liu, Qiongming; Postigo-Fernandez, Jorge et al. (2018) PPAR? deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects. J Clin Invest 128:2600-2612
Cui, Xuan; Jauregui, Ruben; Park, Karen Sophia et al. (2018) Multimodal characterization of a novel mutation causing vitamin B6-responsive gyrate atrophy. Ophthalmic Genet 39:512-516
Evans, Lucy P; Newell, Elizabeth A; Mahajan, MaryAnn et al. (2018) Acute vitreoretinal trauma and inflammation after traumatic brain injury in mice. Ann Clin Transl Neurol 5:240-251
Nathan, J; Ruscitto, A; Pylawka, S et al. (2018) Fibrocartilage Stem Cells Engraft and Self-Organize into Vascularized Bone. J Dent Res 97:329-337
Dieck, Chelsea L; Tzoneva, Gannie; Forouhar, Farhad et al. (2018) Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell 34:136-147.e6
Sengillo, Jesse D; Lee, Winston; Bakhoum, Mathieu F et al. (2018) CHOROIDEREMIA ASSOCIATED WITH A NOVEL SYNONYMOUS MUTATION IN GENE ENCODING REP-1. Retin Cases Brief Rep 12 Suppl 1:S67-S71
Kratchmarov, Radomir; Viragova, Sara; Kim, Min Jung et al. (2018) Metabolic control of cell fate bifurcations in a hematopoietic progenitor population. Immunol Cell Biol 96:863-871

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