Abstract

The Center for Cancer Research is dedicated to investigations of the basic aspects of the development of cancer in mammals. These investigations are multidiscipline and have a synergic cohesion by inclusion into one physical structure. Research on the cellular, molecular and genetic basis of cancer is organized into three program areas: Cancer Immunology, Cancer Cell Biology, and Tumor Virology and Genetics. Many of the studies in the Cancer Immunology Program are concerned with genetic mechanisms underlying the diversity of immune response of both T and B lymphocytes. In addition, cellular processes controlling immunological reactions are being investigated. The Cancer Cell Biology Program has research efforts in the general area of the synthesis and modification of proteins on the surface of cells and the relationship between extracellular structure, cell morphology, and cell growth. The Tumor Virology and Genetics Program has a major emphasis on the activity of oncogenes in the development of cancer. This includes investigations of the regulations of gene expression by oncogenes, activation of oncogenes and development of methodologies for genetic analysis of human diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-20
Application #
3101370
Study Section
Cancer Center Support Review Committee (CCS)
Project Start
1975-09-01
Project End
1995-04-30
Budget Start
1991-05-01
Budget End
1992-04-30
Support Year
20
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Wong, Madeline Y; Chen, Kenny; Antonopoulos, Aristotelis et al. (2018) XBP1s activation can globally remodel N-glycan structure distribution patterns. Proc Natl Acad Sci U S A 115:E10089-E10098
Viswanathan, Srinivas R; Nogueira, Marina F; Buss, Colin G et al. (2018) Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet 50:937-943
Goods, Brittany A; Vahey, Jacqueline M; Steinschneider, Arthur F et al. (2018) Blood handling and leukocyte isolation methods impact the global transcriptome of immune cells. BMC Immunol 19:30
Kaczmarek, James C; Kauffman, Kevin J; Fenton, Owen S et al. (2018) Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells. Nano Lett 18:6449-6454
Perez, Dahlia E; Henle, Andrea M; Amsterdam, Adam et al. (2018) Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology. Pigment Cell Melanoma Res 31:604-613
Wu, Connie; Li, Jiahe; Wang, Wade et al. (2018) Rationally Designed Polycationic Carriers for Potent Polymeric siRNA-Mediated Gene Silencing. ACS Nano 12:6504-6514
Ordovas-Montanes, Jose; Dwyer, Daniel F; Nyquist, Sarah K et al. (2018) Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature 560:649-654
Lam, Fred C; Morton, Stephen W; Wyckoff, Jeffrey et al. (2018) Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Nat Commun 9:1991
Chiu, Anthony C; Suzuki, Hiroshi I; Wu, Xuebing et al. (2018) Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Mol Cell 69:648-663.e7
Weidberg, Hilla; Amon, Angelika (2018) MitoCPR-A surveillance pathway that protects mitochondria in response to protein import stress. Science 360:

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