Abstract

The Center for Cancer Research is dedicated to investigations of the basic aspects of the development of cancer in mammals. These investigations are multidiscipline and have a synergic cohesion by inclusion into one physical structure. Research on the cellular, molecular and genetic basis of cancer is organized into three program areas: Cancer Immunology, Cancer Cell Biology, and Tumor Virology and Genetics. Many of the studies in the Cancer Immunology Program are concerned with genetic mechanisms underlying the diversity of immune response of both T and B lymphocytes. In addition, cellular processes controlling immunological reactions are being investigated. The Cancer Cell Biology Program has research efforts in the general area of the synthesis and modification of proteins on the surface of cells and the relationship between extracellular structure, cell morphology, and cell growth. The Tumor Virology and Genetics Program has a major emphasis on the activity of oncogenes in the development of cancer. This includes investigations of the regulations of gene expression by oncogenes, activation of oncogenes and development of methodologies for genetic analysis of human diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-20
Application #
3101370
Study Section
Cancer Center Support Review Committee (CCS)
Project Start
1975-09-01
Project End
1995-04-30
Budget Start
1991-05-01
Budget End
1992-04-30
Support Year
20
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Tentori, Augusto M; Nagarajan, Maxwell B; Kim, Jae Jung et al. (2018) Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays. Lab Chip 18:2410-2424
Parisi, Tiziana; Balsamo, Michele; Gertler, Frank et al. (2018) The Rb tumor suppressor regulates epithelial cell migration and polarity. Mol Carcinog 57:1640-1650
Gam, Jeremy J; Babb, Jonathan; Weiss, Ron (2018) A mixed antagonistic/synergistic miRNA repression model enables accurate predictions of multi-input miRNA sensor activity. Nat Commun 9:2430
Chen, Huihui; Cho, Kin-Sang; Vu, T H Khanh et al. (2018) Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. Nat Commun 9:3209
Tam, Brooke E; Hao, Yining; Sikes, Hadley D (2018) An examination of critical parameters in hybridization-based epigenotyping using magnetic microparticles. Biotechnol Prog 34:1589-1595
Ramadi, Khalil B; Dagdeviren, Canan; Spencer, Kevin C et al. (2018) Focal, remote-controlled, chronic chemical modulation of brain microstructures. Proc Natl Acad Sci U S A 115:7254-7259
Knouse, Kristin A; Lopez, Kristina E; Bachofner, Marc et al. (2018) Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture. Cell 175:200-211.e13
Sabari, Benjamin R; Dall'Agnese, Alessandra; Boija, Ann et al. (2018) Coactivator condensation at super-enhancers links phase separation and gene control. Science 361:
Clancy-Thompson, Eleanor; Devlin, Christine A; Tyler, Paul M et al. (2018) Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell-Effector Responses. Cancer Immunol Res 6:1524-1536
Fiedler, Eleanor R C; Bhutkar, Arjun; Lawler, Emily et al. (2018) In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1 + BCP-ALL. Blood Adv 2:1229-1242

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