Abstract

) This long established facility has been refurbished and relocated to smaller space but continues to provide high quality and custom-made culture media at a significantly reduced cost. This facility prepares and tests essential culture media and sterile solutions for use by all laboratories in the CCR. Media prepared include both standard formulations of bacterial and tissue culture media as well as customized media for particular experimental needs that is not commercially available. It currently serves all groups in E17/E18 and several other Cancer Center laboratories. Professor Angelika Amon supervises this facility: she sets policy as to what can be prepared by the facility, prioritizing needs and offering scientific advice. The budget request is not significantly increased over approved prior funding despite increased CCR headcount and research volume. The facility is supported by this CCSG (60 percent) and by user chargebacks (40 percent). The budget request represents 4.67 percent of the total budget.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014051-31
Application #
6591551
Study Section
Project Start
2002-05-01
Project End
2003-04-30
Budget Start
Budget End
Support Year
31
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Wong, Madeline Y; Chen, Kenny; Antonopoulos, Aristotelis et al. (2018) XBP1s activation can globally remodel N-glycan structure distribution patterns. Proc Natl Acad Sci U S A 115:E10089-E10098
Viswanathan, Srinivas R; Nogueira, Marina F; Buss, Colin G et al. (2018) Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet 50:937-943
Goods, Brittany A; Vahey, Jacqueline M; Steinschneider, Arthur F et al. (2018) Blood handling and leukocyte isolation methods impact the global transcriptome of immune cells. BMC Immunol 19:30
Kaczmarek, James C; Kauffman, Kevin J; Fenton, Owen S et al. (2018) Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells. Nano Lett 18:6449-6454
Perez, Dahlia E; Henle, Andrea M; Amsterdam, Adam et al. (2018) Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology. Pigment Cell Melanoma Res 31:604-613
Wu, Connie; Li, Jiahe; Wang, Wade et al. (2018) Rationally Designed Polycationic Carriers for Potent Polymeric siRNA-Mediated Gene Silencing. ACS Nano 12:6504-6514
Ordovas-Montanes, Jose; Dwyer, Daniel F; Nyquist, Sarah K et al. (2018) Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature 560:649-654
Lam, Fred C; Morton, Stephen W; Wyckoff, Jeffrey et al. (2018) Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Nat Commun 9:1991
Chiu, Anthony C; Suzuki, Hiroshi I; Wu, Xuebing et al. (2018) Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Mol Cell 69:648-663.e7
Weidberg, Hilla; Amon, Angelika (2018) MitoCPR-A surveillance pathway that protects mitochondria in response to protein import stress. Science 360:

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