Through collaboration, training and technical assistance, the Kl Bioinformafics & Computing Core (BCC) Facility ensures that Kl researchers and other Kl Core Facilities are positioned to fully utilize the power of bioinformafics and statistics in their research. In the previous period, the BCC has both evolved and expanded its services to respond to the rapid advances and growing demand for computation capabilifies. The BCC provides Kl researchers with bioinformatics expertise in protein and genome sequence analysis and annotation, analysis of a variety of different microarray applicafions and interpretation of data from next generafion sequencing. In addifion, the Core provides the desktop and server-based IT services required to support the data-intensive technologies and applications essential for modern cancer research. In these capacities, the BCC has contributed to the projects of more than 85 researchers in the current funding period. The BCC is staffed by outstanding scientists who are expert in a wide array of computational methodologies and have an established track record for acquiring or developing new approaches. They also offer expert training to help Kl investigators develop their own bioinformafics skills. In the upcoming period, the BCC will confinue its support of a wide range of bioinformafics methods while expanding both scientific and IT capabilities in response to the rapid development of new technologies.
| Rothenberg, Daniel A; Taliaferro, J Matthew; Huber, Sabrina M et al. (2018) A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth. iScience 9:367-381 |
| Kimmerling, Robert J; Prakadan, Sanjay M; Gupta, Alejandro J et al. (2018) Linking single-cell measurements of mass, growth rate, and gene expression. Genome Biol 19:207 |
| Tang, Li; Zheng, Yiran; Melo, Mariane Bandeira et al. (2018) Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery. Nat Biotechnol 36:707-716 |
| Holec, Patrick V; Berleant, Joseph; Bathe, Mark et al. (2018) A Bayesian framework for high-throughput T cell receptor pairing. Bioinformatics : |
| Wong, Madeline Y; Doan, Ngoc Duc; DiChiara, Andrew S et al. (2018) A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production. Biochemistry 57:2814-2827 |
| Danai, Laura V; Babic, Ana; Rosenthal, Michael H et al. (2018) Altered exocrine function can drive adipose wasting in early pancreatic cancer. Nature 558:600-604 |
| Dubbury, Sara J; Boutz, Paul L; Sharp, Phillip A (2018) CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. Nature 564:141-145 |
| Tokatlian, Talar; Kulp, Daniel W; Mutafyan, Andrew A et al. (2018) Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes. Sci Rep 8:16527 |
| Crowell, Laura E; Lu, Amos E; Love, Kerry R et al. (2018) On-demand manufacturing of clinical-quality biopharmaceuticals. Nat Biotechnol : |
| Lo, Justin H; Hao, Liangliang; Muzumdar, Mandar D et al. (2018) iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer. Mol Cancer Ther 17:2377-2388 |
Showing the most recent 10 out of 904 publications
