The Genitourinary (GU) Cancer Program is a multi-disciplinary program focused on the pathogenesis, diagnosis, prevention and treatment of genitourinary malignancies. While the emphasis on this Program has been and will continue to be on bladder and prostate cancers (the most common genitourinary malignancies), we are developing increasing emphasis in renal and testicular cancer as well. The scientific goal of the molecular aspects of genitourinary cancer progression and to translate discoveries into novel diagnostic and therapeutic strategies; (c) to examine the epidemiology of genitourinary cancer in order to develop hypotheses regarding possible causation, molecular etiology, and novel prevention strategies; and (d) to develop and test new surgical, chemotherapeutic, radiotherapeutic, biologic and combined modality approaches to the treatment of genitourinary cancer. These goals are being addressed through our considerable strengths in epidemiology, basic research, translational research, and clinical investigation. The GU Program which was newly proposed in the previous grant cycle, now contains 26 members from eight departments. The Program is supported by 29 peer-reviewed research projects (up from eight peer- reviewed research grants in the previous application) from 14 principal investigators. Funding totals are now over $4.7 million in direct costs annually, and a large proportion of the funded grants are multi- disciplinary. The GI Program is directly supported by the Cancer Center Core Facilities, including major involvement with Biostatistics and Cancer Research Informatics Core Facilities. The Cancer Center also fosters interaction in the GU Program through sponsorship of monthly meetings of the GU Group, GU focused Cancer Center Grand Rounds, and GU Retreats. Thus, the GU Program is an integral and well-integrated part of the USC/Norris Comprehensive Cancer Center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA014089-26
Application #
6457507
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
1980-04-01
Project End
2005-11-30
Budget Start
Budget End
Support Year
26
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Nguyen, Lisa; Wang, Zheng; Chowdhury, Adnan Y et al. (2018) Functional compensation between hematopoietic stem cell clones in vivo. EMBO Rep 19:
Zhou, Beiyun; Flodby, Per; Luo, Jiao et al. (2018) Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest 128:970-984
Tokunaga, Ryuma; Zhang, Wu; Naseem, Madiha et al. (2018) CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation - A target for novel cancer therapy. Cancer Treat Rev 63:40-47
Jadvar, Hossein; Chen, Xiaoyuan; Cai, Weibo et al. (2018) Radiotheranostics in Cancer Diagnosis and Management. Radiology 286:388-400
McSkane, Michelle; Stintzing, Sebastian; Heinemann, Volker et al. (2018) Association Between Height and Clinical Outcome in Metastatic Colorectal Cancer Patients Enrolled Onto a Randomized Phase 3 Clinical Trial: Data From the FIRE-3 Study. Clin Colorectal Cancer 17:215-222.e3
Khanova, Elena; Wu, Raymond; Wang, Wen et al. (2018) Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology 67:1737-1753
Brunette, Laurie L; Mhawech-Fauceglia, Paulette Y; Ji, Lingyun et al. (2018) Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study. BMC Cancer 18:970
Tokunaga, Ryuma; Cao, Shu; Naseem, Madiha et al. (2018) Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy. Clin Colorectal Cancer :
Lang, Julie E; Brownson, Kirstyn E (2018) ASO Author Reflections: The Whole Transcriptome Landscape of Circulating Tumor Cells in Nonmetastatic Breast Cancer. Ann Surg Oncol :
Poulard, Coralie; Baulu, Estelle; Lee, Brian H et al. (2018) Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death. Cell Death Dis 9:1038

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