Abstract

Protocol Specific Research Support is designed to provide research support for the conduct of Phase I, and pilot or feasibility clinical research trials approved by the Clinical Investigations Committee. The CIC functions administratively within the Clinical Investigation Support Office (CISO). Phase I protocols are reviewed by CIC and subsequently by CISO and the Cancer Center Executive Committee. Active trials are reviewed at six month intervals. The Cancer Center Executive Committee exercises full and sole authority in awarding funds to support the trial for a six month interval. This support element is composed of 2.0 FTE Research Nurses and 1.0 FTE Data Manager. Ninety-six patients were accrued to the intramural Phase I and feasibility or pilot protocols and supported by these personnel between July 1, 1998 and June 30, 1999. The application stresses the higher volume of work and the complexity of Phase I type studies. During this period, 28 protocols were recommended for support by this committee and awarded support by the Executive Committee. These included hematology (9), medical oncology (12), gynecologic oncology (3), radiation oncology (3) and pediatric oncology (1). There were a total 384 patients entered into these 28 protocols.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA014089-27S1
Application #
6577736
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
2002-04-02
Project End
2002-11-30
Budget Start
Budget End
Support Year
27
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

McSkane, Michelle; Stintzing, Sebastian; Heinemann, Volker et al. (2018) Association Between Height and Clinical Outcome in Metastatic Colorectal Cancer Patients Enrolled Onto a Randomized Phase 3 Clinical Trial: Data From the FIRE-3 Study. Clin Colorectal Cancer 17:215-222.e3
Khanova, Elena; Wu, Raymond; Wang, Wen et al. (2018) Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology 67:1737-1753
Brunette, Laurie L; Mhawech-Fauceglia, Paulette Y; Ji, Lingyun et al. (2018) Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study. BMC Cancer 18:970
Tokunaga, Ryuma; Cao, Shu; Naseem, Madiha et al. (2018) Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy. Clin Colorectal Cancer :
Lang, Julie E; Brownson, Kirstyn E (2018) ASO Author Reflections: The Whole Transcriptome Landscape of Circulating Tumor Cells in Nonmetastatic Breast Cancer. Ann Surg Oncol :
Poulard, Coralie; Baulu, Estelle; Lee, Brian H et al. (2018) Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death. Cell Death Dis 9:1038
Guo, Yu; Perez, Andrew A; Hazelett, Dennis J et al. (2018) CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops. Genome Biol 19:160
Milam, Joel; Slaughter, Rhona; Tobin, Jessica L et al. (2018) Childhood Cancer Survivorship and Substance Use Behaviors: A Matched Case-Control Study Among Hispanic Adolescents and Young Adults. J Adolesc Health 63:115-117
Singh, Hardeep P; Wang, Sijia; Stachelek, Kevin et al. (2018) Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors. Proc Natl Acad Sci U S A 115:E9391-E9400
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu et al. (2018) Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer. Pharmacogenomics J 18:623-632

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