The aims of the USC Norris Cancer Control Research Program are to elucidate the etiology of cancer risk behaviors in the general population and develop primary prevention interventions that modify cancer risk behavior and enhance secondary prevention, clinical care, and survivorship.
These aims serve the overarching goal of reducing and eliminating cancer health disparities among the populations represented in the USC Norris catchment area, with implications for other populations globally. The Program's goals align with the USC Norris strategic plan by: a) developing and testing new interventions that impact the cancer burden; b) applying cutting-edge technology and methodology to assess exposures and disseminate interventions; and c) spanning the continuum of care from primary prevention to survivorship. A hallmark of this Program has been the application of innovative theory and methodology to develop integrated lines of research on cancer risk behaviors and preventive interventions. Given that the diverse, vulnerable, and disadvantaged members of the catchment area reached by the Program's work also reflect the disparities seen at the US population level and the Program makes significant strides in addressing the mission of NCI's efforts in cancer control and population sciences. Recent achievements of the Program, which is led by two internationally-recognized experts, Mary Ann Pentz (primary prevention) and Anna Wu (secondary prevention and survivorship), include 1) understanding mental health comorbidities with tobacco use to inform more tailored smoking cessation programs for vulnerable smokers who have been unable to quit by other means; 2) promoting cultural values and decreasing perceived cultural discrimination as means to improve tobacco prevention and control efforts with Hispanic youth and adults; and 3) utilizing executive function and mindfulness skills training in primary prevention programs that target diet, physical inactivity, and other cancer risk behaviors in youth and applying such interventions to cancer patients, caregivers, and families to improve treatment outcomes. The 30 members represent five schools and 13 departments at USC, and have $15M in peer-reviewed funding (direct costs), 33% of which is from NCI, 27% from other NIH sources, and 33% from other peer-reviewed funding sources. The Program is highly productive with 756 publications of which 17% are inter-programmatic, 23% intra-programmatic and 53% inter-institutional.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014089-45
Application #
9838180
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
45
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu et al. (2018) Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer. Pharmacogenomics J 18:623-632
Singh, Hardeep P; Wang, Sijia; Stachelek, Kevin et al. (2018) Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors. Proc Natl Acad Sci U S A 115:E9391-E9400
Tsai, Yuan-Li; Ha, Dat P; Zhao, He et al. (2018) Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-? signaling. Proc Natl Acad Sci U S A 115:E4245-E4254
Rodrigues, Luana L S; Morgado, Mariza G; Sahasrabuddhe, Vikrant V et al. (2018) Cervico-vaginal self-collection in HIV-infected and uninfected women from Tapajós region, Amazon, Brazil: High acceptability, hrHPV diversity and risk factors. Gynecol Oncol 151:102-110
Valentin-Torres, Alice; Savarin, Carine; Barnett, Joslyn et al. (2018) Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation. J Neuroinflammation 15:121
Ricker, Charité N; Koff, Rachel B; Qu, Chenxu et al. (2018) Patient communication of cancer genetic test results in a diverse population. Transl Behav Med 8:85-94
Jayne, Jordanna G; Bensman, Timothy J; Schaal, Justin B et al. (2018) Rhesus ?-Defensin-1 Attenuates Endotoxin-induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment. Am J Respir Cell Mol Biol 58:310-319
Tobin, Jessica; Miller, Kimberly A; Baezconde-Garbanati, Lourdes et al. (2018) Acculturation, Mental Health, and Quality of Life among Hispanic Childhood Cancer Survivors: A Latent Class Analysis. Ethn Dis 28:55-60
Harris, Holly R; Babic, Ana; Webb, Penelope M et al. (2018) Polycystic Ovary Syndrome, Oligomenorrhea, and Risk of Ovarian Cancer Histotypes: Evidence from the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev 27:174-182
Lee, Brian H; Stallcup, Michael R (2018) Different chromatin and DNA sequence characteristics define glucocorticoid receptor binding sites that are blocked or not blocked by coregulator Hic-5. PLoS One 13:e0196965

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