Cancer Control and Population Sciences (CCPS) has been re-organized into three research focus areas: 1) Epidemiology, Etiology and Population Genomics Research; 2) Behavioral Research; and 3) Cancer Heath Services, Outcomes, Implementation Sciences, Comparative Effectiveness and Evidence-base policy (CHOICE). Major crosscutting themes, include cancer disparities and cancer health interventions. The overarching scientific goals of CCPS program are to 1) identify environmental, biological, psychosocial, genetic and epigenetic factors that affect cancer risk; 2) develop, implement, evaluate, and disseminate behavioral, communications, psychosocial, and clinical interventions focused on cancer prevention and community health and improving health care and quality of life for cancer survivors and those receiving palliative care; and 3) apply and advance cancer research across the full cancer research continuum (cells to society, prevention to survivorship) to impact the broader contexts of health systems and societal health through quality, economic, and policy studies. Particular strengths of CCPS within the focus areas are investigations in the molecular epidemiology of ovarian, brain, cervix, lung, and head and neck cancers; epigenetics of risk associated with prenatal exposures; tobacco cessation; community and practioner-patient communications; exercise-oncology; obesity; geriatric oncology; mobile health technology (mhealth); big-data platforms for integrating tumor registries with genomics; outcomes and economics; efficacy and economics of precision medicine; economics of end-of-life care; and patient-reported outcomes. CCPS currently comprises 59 primary and 9 secondary members across 13 departments, divisions, schools, and institutes. Despite flat NIH budgets, grant funding remains stable since our last submission, from $22 million in peer reviewed funding in 2009 to $23 million in 2013 (70% of the total direct + indirect funding of $32,561,901). Of the total peer reviewed funds, $7,816,844 (34%) is from NCI. During the recent five-year period, we have published over 1700 peer-reviewed papers; 220 papers (13%) demonstrate intra-programmatic collaborations, 310 papers (18%) demonstrate inter- programmatic collaborations and 91 (5%) demonstrated both inter- and intra-programmatic collaborations. Thus, more than a third of the publications represent inter- and/or intra-programmatic collaborations

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-45
Application #
9620054
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-01-01
Budget End
2019-12-31
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Feng, Yun; Wang, Yanru; Liu, Hongliang et al. (2018) Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer. Mol Carcinog 57:216-224
Naqvi, Ibtehaj; Gunaratne, Ruwan; McDade, Jessica E et al. (2018) Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis. Mol Ther 26:1020-1031
Wen, Juyi; Liu, Hongliang; Wang, Lili et al. (2018) Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy. J Thorac Oncol 13:660-675
Li, Bo; Wang, Yanru; Xu, Yinghui et al. (2018) Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival. Int J Cancer 142:2303-2312
Gearhart-Serna, Larisa M; Jayasundara, Nishad; Tacam Jr, Moises et al. (2018) Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations. J Environ Public Health 2018:5610462
Bakthavatsalam, Subha; Sleeper, Mark L; Dharani, Azim et al. (2018) Leveraging ?-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells. Angew Chem Int Ed Engl 57:12780-12784
Dai, Ziwei; Mentch, Samantha J; Gao, Xia et al. (2018) Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. Nat Commun 9:1955
Powell Gray, Bethany; Kelly, Linsley; Ahrens, Douglas P et al. (2018) Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer. Proc Natl Acad Sci U S A 115:4761-4766
Abdi, Khadar; Lai, Chun-Hsiang; Paez-Gonzalez, Patricia et al. (2018) Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun 9:1655
Hudson, Kathryn E; Rizzieri, David; Thomas, Samantha M et al. (2018) Dose-intense chemoimmunotherapy plus radioimmunotherapy in high-risk diffuse large B-cell lymphoma and mantle cell lymphoma: a phase II study. Br J Haematol :

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