? INFORMATION SYSTEMS SHARED RESOURCE The Duke Cancer Institute Information Systems (DCI-IS) shared resource provides critical information systems and expertise to support DCI members with the clinical, translational, and basic biomedical research. The goal of the resource is to deliver comprehensive computational support that provides DCI investigators the breadth of technology to accomplish their research goals. DCI-IS is available to DCI members and their laboratories and personnel at no charge. Support for DCI-IS comes from a combination of Cancer Center Support Grant, DCI and institutional funding. In addition to infrastructure, DCI-IS provides DCI members technical support, application and hardware assistance, and consultation for database development, application development, and web development. The resource provides call-in support, assistance, and consultation for electronic data capture (EDC), database development, application development, website development and server provisioning. In addition to application and data server support, DCI-IS provides support for large scale servers and software for the DCI's Biostatistics and Bioinformatics shared resource. DCI-IS leverages the Duke IT and Informatics resources, including Duke Health Technology Solutions (DHTS), Duke Office of Instructional Technology (OIT), Duke Office of Clinical Research (DOCR), and other institutional groups to leverage enterprise-level IT expertise, experience, and resources to efficiently meet the needs of DCI members. Several primary benefits of DCI-IS for DCI members are: 1) an agile, experienced team, highly skilled in cancer research- related IT; 2) specialized support; 3) 21CFR Part 11-compliant electronic data capture (EDC) system development; 4) user training and ongoing support; 5) expeditious responses to complex and intricate requests; 6) provisioning of infrastructure; and 7) hardware and software to meet the computing needs of both DCI members and other DCI-based shared resources. In 2018, DCI-IS provided services to 164 investigators, 100% of whom were DCI members, accounting for 100% of usage, from all 8 DCI Research Programs. Use of DCI-IS by DCI members contributed to 138 publications over the current project period, 23 of which were in high impact journals (Impact Factor>9), demonstrating the value of DCI-IS services.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-47
Application #
10118128
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-01-01
Project End
2024-12-31
Budget Start
2021-01-01
Budget End
2021-12-31
Support Year
47
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Feng, Yun; Wang, Yanru; Liu, Hongliang et al. (2018) Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer. Mol Carcinog 57:216-224
Naqvi, Ibtehaj; Gunaratne, Ruwan; McDade, Jessica E et al. (2018) Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis. Mol Ther 26:1020-1031
Wen, Juyi; Liu, Hongliang; Wang, Lili et al. (2018) Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy. J Thorac Oncol 13:660-675
Li, Bo; Wang, Yanru; Xu, Yinghui et al. (2018) Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival. Int J Cancer 142:2303-2312
Gearhart-Serna, Larisa M; Jayasundara, Nishad; Tacam Jr, Moises et al. (2018) Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations. J Environ Public Health 2018:5610462
Bakthavatsalam, Subha; Sleeper, Mark L; Dharani, Azim et al. (2018) Leveraging ?-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells. Angew Chem Int Ed Engl 57:12780-12784
Dai, Ziwei; Mentch, Samantha J; Gao, Xia et al. (2018) Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. Nat Commun 9:1955
Powell Gray, Bethany; Kelly, Linsley; Ahrens, Douglas P et al. (2018) Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer. Proc Natl Acad Sci U S A 115:4761-4766
Abdi, Khadar; Lai, Chun-Hsiang; Paez-Gonzalez, Patricia et al. (2018) Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun 9:1655
Hudson, Kathryn E; Rizzieri, David; Thomas, Samantha M et al. (2018) Dose-intense chemoimmunotherapy plus radioimmunotherapy in high-risk diffuse large B-cell lymphoma and mantle cell lymphoma: a phase II study. Br J Haematol :

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