The Biostatistics Shared Resource (BSR) has been an integral component in the research endeavor of the UWCCC for over 30 years. Faculty members of the BSR are essential collaborative members in each of the six Scientific Programs. The mission of the BSR is to promote excellence in cancer research at UWCCC by providing crucial biostatistical support and expertise and by collaborating with UWCCC members in research ranging from laboratory, to clinical, to population science.
The Specific Aims of the BSR are 1) to continue high quality Biostatistics collaboration by valuing an interdisciplinary approach to science, by dedicating effort to collaboration with UWCCC members, and by building synergy between collaborative and methodological statistical research; and 2) to ensure cost-effective Biostatistics collaboration by matching BSR faculty and staff with disease areas, standardizing operations and data analysis tools, drawing on the wealth of faculty expertise, and refining management structure. To address these Aims, BSR staff contribute to UWCCC research design, development, data analysis, and communication of results. BSR staff facilitate the selection of adequate study subjects, assist in the identification of suitable study endpoints, provide sample size estimations or power analyses, conduct and provide interim monitoring for studies, analyze results for presentation of research findings at scientific meetings, and prepare final technical reports for scientific publication. Over 178 collaborative publications and 54 funded collaborative UWCCC member's grants during 2012-2016 not only attest to the value of the BSR, but also serve as documentation of the BSR's contribution to UWCCC research. Biomedical researchers at UW-Madison, and at other NCI designated cancer centers, have adopted this model of collaboration, instead of mere consultation. The BSR responds to the evolving needs and research capacity of the UWCCC by proactively adding and realigning biostatistics faculty members and masters-level statisticians/data analysts. Collaboration with UWCCC members generates new ideas for statistical methodology research and promotes statistical theory and methodology development. These new ideas are used to solve the original scientific questions, completing the full cycle of collaboration and scientific interaction. The BSR continues to serve as a model of very productive interaction at the UWCCC and remains a highly utilized and impactful resource with a considerable number of collaborative grants and publications. The BSR and its staff of highly trained biostatisticians who provide extensive collaborative and independent cancer research and education, are critical to the UWCCC's mission of lessening the burden of cancer in our catchment and beyond.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014520-45
Application #
9706757
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Romero-Masters, James C; Ohashi, Makoto; Djavadian, Reza et al. (2018) An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model. PLoS Pathog 14:e1007221
Xu, Cheng; Chen, Feng; Valdovinos, Hector F et al. (2018) Bacteria-like mesoporous silica-coated gold nanorods for positron emission tomography and photoacoustic imaging-guided chemo-photothermal combined therapy. Biomaterials 165:56-65
Wargowski, Ellen; Johnson, Laura E; Eickhoff, Jens C et al. (2018) Prime-boost vaccination targeting prostatic acid phosphatase (PAP) in patients with metastatic castration-resistant prostate cancer (mCRPC) using Sipuleucel-T and a DNA vaccine. J Immunother Cancer 6:21
Bednarz, Bryan; Grudzinski, Joseph; Marsh, Ian et al. (2018) Murine-specific Internal Dosimetry for Preclinical Investigations of Imaging and Therapeutic Agents. Health Phys 114:450-459
Schrager, Sarina; Burnside, Elizabeth (2018) Breast Cancer Screening in Primary Care: A Call for Development and Validation of Patient-Oriented Shared Decision-Making Tools. J Womens Health (Larchmt) :
van den Broek, Jeroen J; van Ravesteyn, Nicolien T; Mandelblatt, Jeanne S et al. (2018) Comparing CISNET Breast Cancer Incidence and Mortality Predictions to Observed Clinical Trial Results of Mammography Screening from Ages 40 to 49. Med Decis Making 38:140S-150S
Lu, Zhanping; Hong, Courtney C; Kong, Guangyao et al. (2018) Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence. Cell Rep 22:1545-1559
Shea, Michael P; O'Leary, Kathleen A; Fakhraldeen, Saja A et al. (2018) Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ER?+ Mammary Carcinomas. Cancer Res 78:1672-1684
Carroll, Molly J; Fogg, Kaitlin C; Patel, Harin A et al. (2018) Alternatively-Activated Macrophages Upregulate Mesothelial Expression of P-Selectin to Enhance Adhesion of Ovarian Cancer Cells. Cancer Res 78:3560-3573
Ehlerding, Emily B; Grodzinski, Piotr; Cai, Weibo et al. (2018) Big Potential from Small Agents: Nanoparticles for Imaging-Based Companion Diagnostics. ACS Nano 12:2106-2121

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