Immunology and Cancer

Bluestone, Jeffrey A.

Abstract

The overall goal of the UCCRC program in Immunology and Cancer is to dissect the multiple closely interrelated factors that determine immune responses to conventional and tumor antigens. This program is closely related to the Committee on Immunology which has been highly successful in developing interactive research and educational efforts to enhance the scientific endeavors of the UCCRC and the University. One example of the interactive nature of this program is the ongoing USPHS-NCI Program Project: """"""""Immunity and Cancer"""""""" H. Schreiber, Program Director. The overall goals of the UCCRC Program in Immunology and Cancer are: (1) to enhance the scientific interactions among the various immunology researchers interested in cancer; (2) to bring together individuals interested in the most basic elements of the immune response to coordinate efforts towards a better understanding of tumor immunology; (3) to develop organized educational programs for predoctoral and postdoctoral students in order to foster increased interest in cancer research and (4) to manipulate the immune system in the treatment of cancer. Ultimately, these activities will lead to developing preclinical models to test novel immunotherapies for cancer and clinical studies through collaborative efforts with the Developmental Therapeutics Program of the UCCRC.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 5P30CA014599-21
• Application #: 3748903
• Support Year: 21
• Fiscal Year: 1994

Institution

• Name: University of Chicago
• DUNS #: 225410919
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60637

Publications

Hope, C Matthew; Webber, Jemma L; Tokamov, Sherzod A et al. (2018) Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Elife 7:

Wu, Chengyue; Pineda, Federico; Hormuth 2nd, David A et al. (2018) Quantitative analysis of vascular properties derived from ultrafast DCE-MRI to discriminate malignant and benign breast tumors. Magn Reson Med :

Wong, Gabrielle S; Zhou, Jin; Liu, Jie Bin et al. (2018) Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med 24:968-977

Ni, Kaiyuan; Lan, Guangxu; Chan, Christina et al. (2018) Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun 9:2351

Meisel, Marlies; Hinterleitner, Reinhard; Pacis, Alain et al. (2018) Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 557:580-584

Webber, Jemma L; Zhang, Jie; Massey, Alex et al. (2018) Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila. Development 145:

Wei, Jiangbo; Liu, Fange; Lu, Zhike et al. (2018) Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Mol Cell 71:973-985.e5

Boisclair Lachance, Jean-François; Webber, Jemma L; Hong, Lu et al. (2018) Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. Genes Dev 32:389-401

Szmulewitz, Russell Z; Peer, Cody J; Ibraheem, Abiola et al. (2018) Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer. J Clin Oncol 36:1389-1395

Maron, Steven B; Alpert, Lindsay; Kwak, Heewon A et al. (2018) Targeted Therapies for Targeted Populations: Anti-EGFR Treatment for EGFR-Amplified Gastroesophageal Adenocarcinoma. Cancer Discov 8:696-713