Abstract

This application requests continuing support for the Cancer Research Center at the University of Chicago (UCCRC). The 157 members of the UCCRC are organized into seven established programs (Molecular Biology of Cell Growth and Differentiation; Cancer Molecular Genetics; Immunology and Cancer; Clinical and Experimental Therapeutics, Advanced Imaging, Genitourinary Oncology, and Clinical Cancer Genetics and Prevention). Clinical research is a major focus of multidisciplinary activity at the UCCRC. Over 750 individual patients (870 enrollments) were accrued in 2000 on protocols supported, in part, by NCI cooperative agreements and contracts to conduct phase 1, phase II and phase III clinical trials. The UCCRC is the host institution for the Cancer and Leukemia Group B (CALGB) and also participates in the Radiation Therapy Oncology Group, the Gynecologic Oncology Group and the Children's Oncology Group. Funds are requested in this application for Senior and Program Leaders, Planning and Evaluation, Developmental Funds, Administration, Protocol Specific Research, the Protocol Review and Monitoring System and fourteen shared resources/facilities (Transgenic Mouse/Embryonic Stem Cell; DNA Sequencing; Oligopeptide Synthesis; Immunology Applications; Electron Microscopy; Pharmacology Core; Scientific Visualization and Image Analysis; Digital Light Microscopy; Human Immunological Monitoring; Magnetic Resonance Imaging and Spectroscopy; Functional Genomics; Laser Capture Microdissection; Protocol and Data Management Office and Biostatistics and Information Technology). The overall goal of the UCCRC is to discover and translate new cancer-specific knowledge to prevent, detect and treat cancer; specifically (1) to discover and develop new biological knowledge; (2) to discover and develop new clinical treatments for cancer; (3) to discover and develop new technology useful in addressing the problem of cancer and (4) to discover and develop new approaches to prevent cancer. By stimulating and supporting collaborative interdisciplinary cancer-focused research in molecular biology, genetics, immunology and imaging, by translating both UCCRC discoveries and those of other centers to multidisciplinary clinical treatment programs for patients with cancer, and conducting genetics-based cancer screening and prevention research, the UCCRC will reduce the public health burden of cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA014599-31S1
Application #
7119356
Study Section
Subcommittee G - Education (NCI)
Program Officer
Shafik, Hasnaa
Project Start
1977-02-01
Project End
2007-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
31
Fiscal Year
2005
Total Cost
$200,000
Indirect Cost

  Institution

Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Hope, C Matthew; Webber, Jemma L; Tokamov, Sherzod A et al. (2018) Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Elife 7:
Wu, Chengyue; Pineda, Federico; Hormuth 2nd, David A et al. (2018) Quantitative analysis of vascular properties derived from ultrafast DCE-MRI to discriminate malignant and benign breast tumors. Magn Reson Med :
Wong, Gabrielle S; Zhou, Jin; Liu, Jie Bin et al. (2018) Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med 24:968-977
Ni, Kaiyuan; Lan, Guangxu; Chan, Christina et al. (2018) Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun 9:2351
Meisel, Marlies; Hinterleitner, Reinhard; Pacis, Alain et al. (2018) Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 557:580-584
Webber, Jemma L; Zhang, Jie; Massey, Alex et al. (2018) Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila. Development 145:
Wei, Jiangbo; Liu, Fange; Lu, Zhike et al. (2018) Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Mol Cell 71:973-985.e5
Boisclair Lachance, Jean-François; Webber, Jemma L; Hong, Lu et al. (2018) Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. Genes Dev 32:389-401
Szmulewitz, Russell Z; Peer, Cody J; Ibraheem, Abiola et al. (2018) Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer. J Clin Oncol 36:1389-1395
Kudron, Michelle M; Victorsen, Alec; Gevirtzman, Louis et al. (2018) The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of Drosophila and Caenorhabditis elegans Transcription Factors. Genetics 208:937-949

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