Abstract

The Pharmacology Core Facility conducts clinical pharmacology, biochemical correlates, andpharmacogenetic studies with the aim of improving the quality of life and outcome for cancer patients.The Facility is essential for the development, validation, and implementation of analytical methods toassess the effect of pharmacokinetics or pharmacodynamics, and for measuring biochemical correlatesnecessary to optimize drug administration schedules. Some novel anticancer therapies requiredetermination of the optimal dose based on a biochemical endpoint and the Pharmacology Core isequipped to define the bio-modulatory dose. The Facility offers DMA and RNA isolation forpharmacogenetic studies. The Scientific Director of the Facility is M. Eileen Dolan, PhD, and theTechnical Directors are Jacqueline Ramirez, MS (Analytical Component) and Shannon Delaney(Biochemical Component). Dr. Dolan has extensive experience in biochemical enzyme assays, drugmetabolism, and pharmacokinetic/pharmacodynamic studies of anticancer agents. Ms. Ramirez andDelaney are responsible for quality control, analytical method development, maintenance of analyticalequipment, and preparation of reports. The Facility renders analytical and biochemical services toinvestigators within the University (both members and non-members of the UCCRC), as well asinvestigators at other Cancer Centers. In addition, Dr. Dolan provides consultative services on studyand assay design.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA014599-33
Application #
7714295
Study Section
Special Emphasis Panel (ZCA1-RTRB-N (J1))
Project Start
2008-07-22
Project End
2013-03-31
Budget Start
2008-07-22
Budget End
2009-03-31
Support Year
33
Fiscal Year
2008
Total Cost
$82,879
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Sample, Ashley; He, Yu-Ying (2018) Mechanisms and prevention of UV-induced melanoma. Photodermatol Photoimmunol Photomed 34:13-24
Jeong, Choongwon; Witonsky, David B; Basnyat, Buddha et al. (2018) Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal. PLoS Genet 14:e1007650
Wang, Xin; Wu, Xingye; Zhang, Zhonglin et al. (2018) Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway. Sci Rep 8:17914
Brown, Hailey M; Biering, Scott B; Zhu, Allen et al. (2018) Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases. Bioessays 40:e1700231
Karrison, Theodore; Kocherginsky, Masha (2018) Restricted mean survival time: Does covariate adjustment improve precision in randomized clinical trials? Clin Trials 15:178-188
An, Ningfei; Khan, Saira; Imgruet, Molly K et al. (2018) Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS. Blood 131:2682-2697
Trujillo, Jonathan A; Sweis, Randy F; Bao, Riyue et al. (2018) T Cell-Inflamed versus Non-T Cell-Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection. Cancer Immunol Res 6:990-1000
Zeng, Zongyue; Huang, Bo; Huang, Shifeng et al. (2018) The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs. Genes Dis 5:62-74
Lee, Ji-Hye; Park, Beom Seok; Han, Kang R et al. (2018) Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication. Front Microbiol 9:1466
Cheng, Jason X; Chen, Li; Li, Yuan et al. (2018) RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. Nat Commun 9:1163

Showing the most recent 10 out of 668 publications