Pharmacology

Dolan, M Eileen

Abstract

The Pharmacology Core Facility conducts clinical pharmacology, biochemical correlates, and pharmacogenetic studies with the aim of improving the quality of life and outcome for cancer patients. The Facility is essential for the development, validation, and implementation of analytical methods to assess the effect of pharmacokinetics or pharmacodynamics, and for measuring biochemical correlates necessary to optimize drug administration schedules. Some novel anticancer therapies require determination of the optimal dose based on a biochemical endpoint and the Pharmacology Core is equipped to define the bio-modulatory dose. The Facility offers DMA and RNA isolation for pharmacogenetic studies. The Scientific Director of the Facility is M. Eileen Dolan, PhD, and the Technical Directors are Jacqueline Ramirez, MS (Analytical Component) and Shannon Delaney (Biochemical Component). Dr. Dolan has extensive experience in biochemical enzyme assays, drug metabolism, and pharmacokinetic/pharmacodynamic studies of anticancer agents. Ms. Ramirez and Delaney are responsible for quality control, analytical method development, maintenance of analytical equipment, and preparation of reports. The Facility renders analytical and biochemical services to investigators within the University (both members and non-members of the UCCRC), as well as investigators at other Cancer Centers. In addition, Dr. Dolan provides consultative services on study and assay design.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 5P30CA014599-34
• Application #: 7843297
• Study Section: Special Emphasis Panel (ZCA1)
• Budget Start: 2009-04-01
• Budget End: 2010-03-31
• Support Year: 34
• Fiscal Year: 2009
• Total Cost: $133,465

Institution

• Name: University of Chicago
• DUNS #: 005421136
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60637

Publications

Hope, C Matthew; Webber, Jemma L; Tokamov, Sherzod A et al. (2018) Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Elife 7:

Wu, Chengyue; Pineda, Federico; Hormuth 2nd, David A et al. (2018) Quantitative analysis of vascular properties derived from ultrafast DCE-MRI to discriminate malignant and benign breast tumors. Magn Reson Med :

Wong, Gabrielle S; Zhou, Jin; Liu, Jie Bin et al. (2018) Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med 24:968-977

Ni, Kaiyuan; Lan, Guangxu; Chan, Christina et al. (2018) Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun 9:2351

Meisel, Marlies; Hinterleitner, Reinhard; Pacis, Alain et al. (2018) Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 557:580-584

Webber, Jemma L; Zhang, Jie; Massey, Alex et al. (2018) Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila. Development 145:

Wei, Jiangbo; Liu, Fange; Lu, Zhike et al. (2018) Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Mol Cell 71:973-985.e5

Boisclair Lachance, Jean-François; Webber, Jemma L; Hong, Lu et al. (2018) Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. Genes Dev 32:389-401

Szmulewitz, Russell Z; Peer, Cody J; Ibraheem, Abiola et al. (2018) Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer. J Clin Oncol 36:1389-1395

Kudron, Michelle M; Victorsen, Alec; Gevirtzman, Louis et al. (2018) The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of Drosophila and Caenorhabditis elegans Transcription Factors. Genetics 208:937-949