Pharmacology

Dolan, M Eileen

Abstract

The Pharmacology Core Facility conducts clinical pharmacology, biochemical correlates, and pharmacogenetic studies with the aim of improving the quality of life and outcome for cancer patients. The Facility is essential for the development, validation, and implementation of analytical methods to assess the effect of pharmacokinetics or pharmacodynamics, and for measuring biochemical correlates necessary to optimize drug administration schedules. Some novel anticancer therapies require determination of the optimal dose based on a biochemical endpoint and the Pharmacology Core is equipped to define the bio-modulatory dose. The Facility offers DMA and RNA isolation for pharmacogenetic studies. The Scientific Director of the Facility is M. Eileen Dolan, PhD, and the Technical Directors are Jacqueline Ramirez, MS (Analytical Component) and Shannon Delaney (Biochemical Component). Dr. Dolan has extensive experience in biochemical enzyme assays, drug metabolism, and pharmacokinetic/pharmacodynamic studies of anticancer agents. Ms. Ramirez and Delaney are responsible for quality control, analytical method development, maintenance of analytical equipment, and preparation of reports. The Facility renders analytical and biochemical services to investigators within the University (both members and non-members of the UCCRC), as well as investigators at other Cancer Centers. In addition, Dr. Dolan provides consultative services on study and assay design.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 5P30CA014599-37
• Application #: 8375706
• Study Section: Special Emphasis Panel (ZCA1-RTRB-N)
• Budget Start: 2012-04-01
• Budget End: 2013-03-31
• Support Year: 37
• Fiscal Year: 2012
• Total Cost: $118,409
• Indirect Cost: $41,391

Institution

• Name: University of Chicago
• DUNS #: 005421136
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60637

Publications

Kathayat, Rahul S; Cao, Yang; Elvira, Pablo D et al. (2018) Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun 9:334

Liu, Jun; Eckert, Mark A; Harada, Bryan T et al. (2018) m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol 20:1074-1083

Bhanvadia, Raj R; VanOpstall, Calvin; Brechka, Hannah et al. (2018) MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease. Clin Cancer Res 24:3668-3680

Wood, Kevin; Byron, Elizabeth; Janisch, Linda et al. (2018) Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms. Am J Clin Oncol 41:963-966

Sample, Ashley; Zhao, Baozhong; Wu, Chunli et al. (2018) The Autophagy Receptor Adaptor p62 is Up-regulated by UVA Radiation in Melanocytes and in Melanoma Cells. Photochem Photobiol 94:432-437

Hrusch, C L; Manns, S T; Bryazka, D et al. (2018) ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s. Mucosal Immunol 11:61-70

Hope, C Matthew; Webber, Jemma L; Tokamov, Sherzod A et al. (2018) Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Elife 7:

Wong, Gabrielle S; Zhou, Jin; Liu, Jie Bin et al. (2018) Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med 24:968-977

Wu, Chengyue; Pineda, Federico; Hormuth 2nd, David A et al. (2018) Quantitative analysis of vascular properties derived from ultrafast DCE-MRI to discriminate malignant and benign breast tumors. Magn Reson Med :

Meisel, Marlies; Hinterleitner, Reinhard; Pacis, Alain et al. (2018) Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 557:580-584