DAVID F. AND MARGARET T. GROHNE FAMILY CANCER IMMUNOLOGY AND IMMUNOTHERAPY PROGRAM PROJECT SUMMARY The Cancer Immunology and Immunotherapy (CII) Program is a longstanding basic and translational sciences program within the Mayo Clinic Cancer Center (MCCC). In 2016, this program was officially endowed by the David F. and Margaret T. Grohne Family. The Program continues to work toward better understanding the mechanisms of immunity, the relationship between inflammation and cancer, and the development of innovative solutions to combat cancer through immune therapy. The CII Program has contributed significantly to checkpoint blockade therapy, which has resulted in a major change in the standard of care of several different cancers. It is now poised to make additional major contributions such as using antibody-targeted chemotherapeutics, effectively targeting melanoma and ovarian cancers, which have proven nonresponsive to established therapies. The Program includes 35 members, representing 14 different departments in the Mayo Clinic College of Medicine and Science. The current membership is a historically highly productive team with a total publication record in excess of 5000 papers that has garnered over 245,000 citations. The main goal of the Program is to provide an interactive, supportive, and durable scientific environment to foster our four principal cutting-edge Specific Aims: (1) To develop new knowledge about how the immune system functions, (2) To develop novel antibody-based therapies for the treatment of cancers (3) To identify and develop vaccine approaches that can be implemented to protect against cancer recurrence and improve the efficacy of immune modulation with checkpoint inhibitors, and (4) To develop innovative strategies to redirect non-tumor antigen- specific T cells to attack cancer. The CII Program has been consistently well-funded and currently is supported by extramural peer-reviewed grants totaling $3.6M in direct costs of which ~35% are from NCI. Direct funding from non-peer-reviewed grants is $8.4M resulting in an overall total of $12M. This is a 20% increase over the last funding period. In the 2013-2017 timeframe, Program members published 650 cancer-related publications, of which 19% were intraprogrammatic, 57% were interprogrammatic, and 124 were published in journals with impact factors ?10, reflecting the quality of the work and illustrating the high degree of interaction the CII Program members have with members of other MCCC Programs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA015083-47
Application #
10113607
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-04-25
Project End
2024-02-29
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
47
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Liu, Gang; Mukherjee, Bhramar; Lee, Seunggeun et al. (2018) Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence. Am J Epidemiol 187:366-377
Ong, Jue-Sheng; Hwang, Liang-Dar; Cuellar-Partida, Gabriel et al. (2018) Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. Int J Epidemiol 47:450-459
Kumar, Shaji K; Buadi, Francis K; LaPlant, Betsy et al. (2018) Phase 1/2 trial of ixazomib, cyclophosphamide and dexamethasone in patients with previously untreated symptomatic multiple myeloma. Blood Cancer J 8:70
Schafer, Eric S; Rau, Rachel E; Berg, Stacey et al. (2018) A phase 1 study of eribulin mesylate (E7389), a novel microtubule-targeting chemotherapeutic agent, in children with refractory or recurrent solid tumors: A Children's Oncology Group Phase 1 Consortium study (ADVL1314). Pediatr Blood Cancer 65:e27066
Kalli, Kimberly R; Block, Matthew S; Kasi, Pashtoon M et al. (2018) Folate Receptor Alpha Peptide Vaccine Generates Immunity in Breast and Ovarian Cancer Patients. Clin Cancer Res 24:3014-3025
Wang, Sophia S; Carrington, Mary; Berndt, Sonja I et al. (2018) HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes. Cancer Res 78:4086-4096
Norris, Robin E; Fox, Elizabeth; Reid, Joel M et al. (2018) Phase 1 trial of ontuxizumab (MORAb-004) in children with relapsed or refractory solid tumors: A report from the Children's Oncology Group Phase 1 Pilot Consortium (ADVL1213). Pediatr Blood Cancer 65:e26944
Block, Matthew S; Vierkant, Robert A; Rambau, Peter F et al. (2018) MyD88 and TLR4 Expression in Epithelial Ovarian Cancer. Mayo Clin Proc 93:307-320
Sharma, Ayush; Oishi, Naoki; Boddicker, Rebecca L et al. (2018) Recurrent STAT3-JAK2 fusions in indolent T-cell lymphoproliferative disorder of the gastrointestinal tract. Blood 131:2262-2266
Langlais, Blake T; Geyer, Holly; Scherber, Robyn et al. (2018) Quality of life and symptom burden among myeloproliferative neoplasm patients: do symptoms impact quality of life? Leuk Lymphoma :1-7

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