Manger, Ronald L.

Abstract

The purpose of the Biologics Production Shared Resource is fourfold: (1) to develop and optimize production of biologic agents in the most cost-effective manner possiblel (2) to optimize methods of purification of biologic agents at high yield; (3) to develop, evaluate and maintain quality control standards for biologic agents intended for intravenous administration in humans and (4) to provide investigators with monoclonal antibodies and other therapeutics in both quantity and form suitable for intravenous administration in humans. Resource activities focus on production and purification of purified antibodies and other cell culture derived products in amounts ranging from milligrams to grams with concomitant support to meet both research and U.S. Food and Drug Administration (FDA) requirements. This application requests continued support for a resource which continues to fulfill an essential role for peer reviewed research within the Consortium.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 2P30CA015704-30
• Application #: 6718530
• Project Start: 2003-03-12
• Project End: 2007-12-31
• Budget Start: 2003-03-12
• Budget End: 2003-12-31
• Support Year: 30
• Fiscal Year: 2003
• Total Cost: $79,966

Institution

• Name: Fred Hutchinson Cancer Research Center
• DUNS #: 078200995
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98109

Publications

Shirts, Brian H; Konnick, Eric Q; Upham, Sarah et al. (2018) Using Somatic Mutations from Tumors to Classify Variants in Mismatch Repair Genes. Am J Hum Genet 103:19-29

Du, Jing; Flynn, Ryan; Paz, Katelyn et al. (2018) Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients. Blood 131:1743-1754

Mora-Pinzon, Maria C; Trentham-Dietz, Amy; Gangnon, Ronald E et al. (2018) Urinary Magnesium and Other Elements in Relation to Mammographic Breast Density, a Measure of Breast Cancer Risk. Nutr Cancer 70:441-446

Verboon, Jeffrey M; Decker, Jacob R; Nakamura, Mitsutoshi et al. (2018) Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulates Drosophila oogenesis. J Cell Sci 131:

Kuzma, Jessica N; Hagman, Derek K; Cromer, Gail et al. (2018) Intra-individual variation in markers of intestinal permeability and adipose tissue inflammation in healthy normal weight to obese adults. Cancer Epidemiol Biomarkers Prev :

Suzuki, Aussie; Gupta, Amitabha; Long, Sarah K et al. (2018) A Kinesin-5, Cin8, Recruits Protein Phosphatase 1 to Kinetochores and Regulates Chromosome Segregation. Curr Biol 28:2697-2704.e3

Thornblade, Lucas W; Mulligan, Michael S; Odem-Davis, Katherine et al. (2018) Challenges in Predicting Recurrence After Resection of Node-Negative Non-Small Cell Lung Cancer. Ann Thorac Surg 106:1460-1467

Adrianse, Robin L; Smith, Kaleb; Gatbonton-Schwager, Tonibelle et al. (2018) Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion. Epigenetics Chromatin 11:50

Walter, Roland B; Othus, Megan; Orlowski, Kaysey F et al. (2018) Unsatisfactory efficacy in randomized study of reduced-dose CPX-351 for medically less fit adults with newly diagnosed acute myeloid leukemia or other high-grade myeloid neoplasm. Haematologica 103:e106-e109

Lee, Dale; Swan, C Kaiulani; Suskind, David et al. (2018) Children with Crohn's Disease Frequently Consume Select Food Additives. Dig Dis Sci 63:2722-2728