Shared Resource: Comparative Medicine

Roble, Gordon

Abstract

COMPARATIVE MEDICINE SHARED RESOURCE (CMSR) The Comparative Medicine Shared Resource (CMSR), located at the Fred Hutch (FH), provides high quality support for preclinical research performed by Consortium investigators. It achieves this through specialized support structures, technology, and personnel expertise. CMSR maintains an AAALAC-accredited, USDA- registered, and PHS-assured facility. CMSR is staffed by three clinical veterinarians with expertise in laboratory animal medicine, animal-use regulations, and facility management and husbandry. An additional 45 personnel provide daily care and treatment to five species of animals currently housed at FH ? mice, rats, dogs, fish, and guinea pigs ? and deliver exceptional husbandry to maintain microbiologic and environmental control of animal colonies. This care encompasses the needs of many specialized animal models of cancer and cancer-related disease states such as transplanted or induced liquid and solid tumors, cancer-related pathogens, graft- versus-host disease, and conditions and treatments related to radiation therapy. The small animal facility is a centralized barrier facility with special areas to accommodate radioactive agents and infectious agents. CMSR specialty services include patient-derived-xenograft (PDX) models and preclinical imaging support in collaboration with the Translational BioImaging Core Shared Resource (TBICSR). A full time veterinary comparative pathologist is available for consultation and collaboration with researchers. Equipment support for CMSR includes individually ventilated micro-isolator rodent cages, a full service rodent cage wash and autoclaves, and numerous surgical-ready procedure rooms for rodent users. Canine support includes specialized housing for Severe Combined Immune Deficiency (SCID) and Pyruvate Kinase (PK) deficient animals, a comprehensive surgical suite and procedure area, and a Linear Accelerator dedicated to preclinical research. CMSR supplies an invaluable, centralized resource to support high quality preclinical studies. Historically, animal models contributed to Nobel Prize winning research in bone marrow transplantation and hematopoietic cancers. The continued expansion of scope and volume of animal-related work now includes solid tumor and cancer-related pathogen research.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 5P30CA015704-46
• Application #: 10125957
• Study Section: Subcommittee I - Transistion to Independence (NCI)
• Project Start: 1997-01-01
• Project End: 2024-12-31
• Budget Start: 2021-01-01
• Budget End: 2021-12-31
• Support Year: 46
• Fiscal Year: 2021

Institution

• Name: Fred Hutchinson Cancer Research Center
• DUNS #: 078200995
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98109

Publications

Briant, Katherine J; Sanchez, Janeth I; Ibarra, Genoveva et al. (2018) Using a Culturally Tailored Intervention to Increase Colorectal Cancer Knowledge and Screening among Hispanics in a Rural Community. Cancer Epidemiol Biomarkers Prev 27:1283-1288

Xu, Chang; Nikolova, Olga; Basom, Ryan S et al. (2018) Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer. Clin Cancer Res 24:2828-2843

Miller, Chris P; Tsuchida, Connor; Zheng, Ying et al. (2018) A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis. Neoplasia 20:610-620

Baker, K Scott; Syrjala, Karen L (2018) Long-term complications in adolescent and young adult leukemia survivors. Hematology Am Soc Hematol Educ Program 2018:146-153

Gavvovidis, Ioannis; Leisegang, Matthias; Willimsky, Gerald et al. (2018) Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell Polyomavirus. Clin Cancer Res 24:3644-3655

Paulson, K G; Voillet, V; McAfee, M S et al. (2018) Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA. Nat Commun 9:3868

Puronen, Camille E; Cassaday, Ryan D; Stevenson, Philip A et al. (2018) Long-Term Follow-Up of 90Y-Ibritumomab Tiuxetan, Fludarabine, and Total Body Irradiation-Based Nonmyeloablative Allogeneic Transplant Conditioning for Persistent High-Risk B Cell Lymphoma. Biol Blood Marrow Transplant 24:2211-2215

Witzky, Anne; Hummels, Katherine R; Tollerson 2nd, Rodney et al. (2018) EF-P Posttranslational Modification Has Variable Impact on Polyproline Translation in Bacillus subtilis. MBio 9:

Rosenthal, Elisabeth A; Shirts, Brian H; Amendola, Laura M et al. (2018) Rare loss of function variants in candidate genes and risk of colorectal cancer. Hum Genet 137:795-806

Verboon, Jeffrey M; Decker, Jacob R; Nakamura, Mitsutoshi et al. (2018) Correction: Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulates Drosophila oogenesis (doi:10.1242/211573). J Cell Sci 131: