? CANCER CONTROL (CC) The Cancer Control (CC) Program at The Ohio State University Comprehensive Cancer Center (OSUCCC), led by Electra Paskett, PhD, and Theodore Wagener, PhD, has 53 members from 21 Departments and 7 OSU Colleges (Arts & Sciences, Dentistry, Education & Human Ecology, Law, Medicine, Nursing, and Public Health). The overall goal of the CC Program is to conduct research to reduce the incidence, mortality and morbidity of cancer in our catchment area, the state of Ohio, and beyond. The CC Program conducts research across the cancer control continuum, from etiology through survivorship, and across the lifespan. Crosscutting themes unite the aims of the program and include policy and underserved/minority populations, with a focus on the priority cancers of the OSUCCC. Our research also capitalizes on our members? strengths, such as epidemiology, biology and behavior, and includes trans-disciplinary research teams to address research aims.
The Specific Aims of the CC Program are to: 1) Identify molecular, genetic, and behavioral factors related to cancer incidence and mortality at a population level; 2) Develop and test behavioral interventions that prevent cancer development or facilitate early detection; and, 3) Assess and intervene on issues of cancer survivorship (including active cancer patients and survivors). CC Program members published 1,028 cancer-relevant manuscripts between 12/01/14 and 11/30/19. Of these, 17% were intra-programmatic (multiple authors from CC Program), 22% were inter-programmatic (authors from multiple OSUCCC Programs), and 74% were multi-institutional (authors from both CC and another institution). The total collaborative publications is 87%. CC Program funding stands at $7.7M in overall direct, cancer-focused funding, of which $6.7M is peer-reviewed, including $6.2M direct funding from NIH ($3.6M from NCI). Over the last 5 years, CC Program members have accrued 21,450 participants to trials; 4,807 to non-therapeutic/interventional trials and 16,643 to non-therapeutic/ non-interventional trials. Future plans for the CC Program include increasing research in: 1) molecular and genetic epidemiology; 2) patient outcomes; 3) survivorship, including the effects of immunotherapy on patient outcomes through collaborations with the new OSUCCC Pelotonia Institute for Immuno-Oncology; and 4) tobacco use and related health-effects through the new OSUCCC Center for Tobacco Research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016058-45
Application #
10089994
Study Section
Subcommittee H - Clinical Groups (NCI)
Project Start
1997-09-12
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Dietrich, Sascha; Ole?, Ma?gorzata; Lu, Junyan et al. (2018) Drug-perturbation-based stratification of blood cancer. J Clin Invest 128:427-445
Chen, Zhong; Wu, Dayong; Thomas-Ahner, Jennifer M et al. (2018) Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13. Proc Natl Acad Sci U S A 115:6810-6815
Moshiri, Farzaneh; Salvi, Alessandro; Gramantieri, Laura et al. (2018) Circulating miR-106b-3p, miR-101-3p and miR-1246 as diagnostic biomarkers of hepatocellular carcinoma. Oncotarget 9:15350-15364
Petrov, Brawnie; Aldoori, Ayat; James, Cindy et al. (2018) Bipolar disorder in youth is associated with increased levels of vitamin D-binding protein. Transl Psychiatry 8:61
Senaras, Caglar; Niazi, Muhammad Khalid Khan; Sahiner, Berkman et al. (2018) Optimized generation of high-resolution phantom images using cGAN: Application to quantification of Ki67 breast cancer images. PLoS One 13:e0196846
Kovac, Rachel L; Ballash, Gregory; Fenger, Joelle et al. (2018) Plasma cytokeratin-18 concentrations as noninvasive biomarker of early gastrointestinal toxicosis in dogs receiving toceranib. J Vet Intern Med 32:2061-2068
Locke, Landon W; Kothandaraman, Shankaran; Tweedle, Michael et al. (2018) Use of a leukocyte-targeted peptide probe as a potential tracer for imaging the tuberculosis granuloma. Tuberculosis (Edinb) 108:201-210
Neff, Robert; Rush, Craig M; Smith, Blair et al. (2018) Functional characterization of recurrent FOXA2 mutations seen in endometrial cancers. Int J Cancer 143:2955-2961
Comiskey Jr, D F; Jacob, A G; Sanford, B L et al. (2018) A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo. Oncogene 37:95-106
Bickell, Nina A; Lin, Jenny J; Abramson, Sarah R et al. (2018) Racial Disparities in Clinically Significant Prostate Cancer Treatment: The Potential Health Information Technology Offers. J Oncol Pract 14:e23-e33

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