Abstract

The Clinical Research Shared Resource consists of the Director, the Office for Clinical Research (centralized protocol office), eight discipline-oriented RN/CRA teams, and a computer programmer and analyst team. In addition, the Clinical Trials Review Committee (PRMS) and its sub-committee, the Monitoring Committee, operate out of the shared resource office. The activities of the Shared Resource provide broad support of clinical cancer research and require the coordinated activities of more than 17 FTEs; it supports a broad range of research with diverse sponsors. The shared resource predominantly is supported by grants, contracts, and MCC discretionary funds. Limited CCSG support (0.95 FTE) is requested for the Director, Administrator, RN consultant, Programmer, and Analyst positions of this resource. These personnel serve leadership, coordination, and quality assurance roles that enhance the efficiency and value of individual research projects or affiliations. CCSG support also is requested for two other aspects of the clinical research operation, specifically, Protocol- specific Research Support (section 9.10; 1.80 1TI,E) and PRMS (section 9.9; 0.35 FTE).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016059-21
Application #
6101747
Study Section
Project Start
1999-02-19
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
21
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Warthan, Michelle D; Washington, Sonya L; Franzese, Samone E et al. (2018) The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma. Biol Reprod 98:309-322
Booth, Laurence; Roberts, Jane L; Rais, Rumeesa et al. (2018) [Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration. Oncotarget 9:6062-6074
Floros, Konstantinos V; Lochmann, Timothy L; Hu, Bin et al. (2018) Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy. Proc Natl Acad Sci U S A 115:E2594-E2603
Brabec, Viktor; Kasparkova, Jana; Menon, Vijay et al. (2018) Polynuclear Platinum Complexes. Structural Diversity and DNA Binding. Met Ions Life Sci 18:
Lv, Dong-Wen; Zhang, Kun; Li, Renfeng (2018) Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. PLoS Pathog 14:e1006868
Rizzo, Juliana; Colombo, Ana C; Zamith-Miranda, Daniel et al. (2018) The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans. Biochim Biophys Acta Mol Cell Res 1865:532-541
Talukdar, Sarmistha; Pradhan, Anjan K; Bhoopathi, Praveen et al. (2018) MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Proc Natl Acad Sci U S A 115:5768-5773
Liu, Runping; Li, Xiaojiaoyang; Huang, Zhiming et al. (2018) C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice. Hepatology 67:1441-1457
Moro, Kazuki; Kawaguchi, Tsutomu; Tsuchida, Junko et al. (2018) Ceramide species are elevated in human breast cancer and are associated with less aggressiveness. Oncotarget 9:19874-19890
El-Rami, Fadi; Kong, Xiangzhen; Parikh, Hardik et al. (2018) Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis. Microbiology 164:173-185

Showing the most recent 10 out of 586 publications