The Massey Cancer Center is an administrative matrix center at Virginia Commonwealth University whose mission is to provide comprehensive cancer services in the areas of basic, clinical, and population research, outreach, and education to the State of Virginia and the nation. The major goals of the Center are 1) to facilitate high-quality basic, clinical, and population-based research focused on the cancer problem and 2) to promote interdisciplinary collaborations among the scientific programs and members of the Center, in order to generate more effective interventions for cancer prevention and treatment. Research activities of the Massey Cancer Center are carried out through five established research programs which are Developmental Therapeutics, Cancer Cell Biology, Immune Mechanisms, Cancer Control, and Radiation Biology and Oncology. The programs are structured to include both basic research and either clinical translational or applied population research so as to facilitate rapid implementation of research findings in the treatment and prevention of cancer. In order to provide support for the predominantly peer-reviewed research base of the Massey Cancer Center programs, several shared resources are operated by the Center including those in Clinical Research, Biostatistics, Flow Cytometry, Hybridoma/Cell Production, Molecular Biology, Nucleic Acid Sequencing and Synthesis, Structural Biology, and Transgenic Mouse. This application requests Cancer Center Support Grant continuation to support these shared resources as well as senior leadership, program leadership, administration, protocol-specific research, planning and evaluation, protocol review and monitoring, and developmental funding which are necessary to facilitate and stimulate interdisciplinary cancer research through the scientific programs of the Center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016059-23
Application #
6463526
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ptak, Krzysztof
Project Start
1978-12-01
Project End
2007-04-30
Budget Start
2002-05-16
Budget End
2003-04-30
Support Year
23
Fiscal Year
2002
Total Cost
$1,788,028
Indirect Cost
Name
Virginia Commonwealth University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Yamada, Akimitsu; Nagahashi, Masayuki; Aoyagi, Tomoyoshi et al. (2018) ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer. Mol Cancer Res 16:1059-1070
Cantwell, Marc T; Farrar, Jared S; Lownik, Joseph C et al. (2018) STAT3 suppresses Wnt/?-catenin signaling during the induction phase of primary Myf5+ brown adipogenesis. Cytokine 111:434-444
Aqbi, Hussein F; Wallace, Matthew; Sappal, Samay et al. (2018) IFN-? orchestrates tumor elimination, tumor dormancy, tumor escape, and progression. J Leukoc Biol :
Volker, Sonja E; Hedrick, Shannon E; Feeney, Yvonne B et al. (2018) Cyclophilin A Function in Mammary Epithelium Impacts Jak2/Stat5 Signaling, Morphogenesis, Differentiation, and Tumorigenesis in the Mammary Gland. Cancer Res 78:3877-3887
Li, Xiaojiaoyang; Liu, Runping; Huang, Zhiming et al. (2018) Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans. Hepatology 68:599-615
Durant, Stephen T; Zheng, Li; Wang, Yingchun et al. (2018) The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. Sci Adv 4:eaat1719
Damle, S R; Martin, R K; Cockburn, C L et al. (2018) ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production. Allergy 73:125-136
Wang, Feng; Li, Hongyan; Markovsky, Ela et al. (2018) Pazopanib radio-sensitization of human sarcoma tumors. Oncotarget 9:9311-9324
Stokes, Nancy A; Stanciu, Cristina E; Brocato, Emily R et al. (2018) Simplification of complex DNA profiles using front end cell separation and probabilistic modeling. Forensic Sci Int Genet 36:205-212
Poklepovic, Andrew; Qu, Yuesheng; Dickinson, Molly et al. (2018) Randomized study of doxorubicin-based chemotherapy regimens, with and without sildenafil, with analysis of intermediate cardiac markers. Cardiooncology 4:

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