Abstract

All cancer-related clinical trials as well as all prevention and control studies are subject to initial and ongoingCancer Center review for scientific merit and scientific progress. The Cancer Center has the authority toinitiate, monitor, and terminate all such research. This authority is exercised by the Protocol Review andMonitoring System (PRMS).The PRMS serves three main functions:(1) Conduct an ongoing evaluation of the scientific merit and scientific progress of all cancer-related clinicaltrials and prevention and control studies at VCU.(2) Establish priorities among protocols potentially competing for patient or research resources.(3) Provide oversight of the management of the Clinical Protocol and Data Monitoring Shared Resource.In pursuit of these functions, PRMS(4) Develops Policies and Procedures for the Oversight of Clinical Research.(5) Reviews reports from investigators.(6) Reviews reports of the Monitoring Committee (MC).(7) Reviews reports from the Data Safety and Monitoring plans, that is, Independent Physician Monitors andData and Safety Monitoring Boards (DSMB).(8) Serves as liaison with the NIH for the purposes of reporting temporary or permanent suspension of NIHfundedprotocols.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016059-28
Application #
7698842
Study Section
Subcommittee G - Education (NCI)
Project Start
2008-09-03
Project End
2011-04-30
Budget Start
2008-09-03
Budget End
2009-04-30
Support Year
28
Fiscal Year
2008
Total Cost
$13,180
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Warthan, Michelle D; Washington, Sonya L; Franzese, Samone E et al. (2018) The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma. Biol Reprod 98:309-322
Booth, Laurence; Roberts, Jane L; Rais, Rumeesa et al. (2018) [Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration. Oncotarget 9:6062-6074
Floros, Konstantinos V; Lochmann, Timothy L; Hu, Bin et al. (2018) Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy. Proc Natl Acad Sci U S A 115:E2594-E2603
Brabec, Viktor; Kasparkova, Jana; Menon, Vijay et al. (2018) Polynuclear Platinum Complexes. Structural Diversity and DNA Binding. Met Ions Life Sci 18:
Lv, Dong-Wen; Zhang, Kun; Li, Renfeng (2018) Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. PLoS Pathog 14:e1006868
Rizzo, Juliana; Colombo, Ana C; Zamith-Miranda, Daniel et al. (2018) The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans. Biochim Biophys Acta Mol Cell Res 1865:532-541
Talukdar, Sarmistha; Pradhan, Anjan K; Bhoopathi, Praveen et al. (2018) MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Proc Natl Acad Sci U S A 115:5768-5773
Liu, Runping; Li, Xiaojiaoyang; Huang, Zhiming et al. (2018) C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice. Hepatology 67:1441-1457
Moro, Kazuki; Kawaguchi, Tsutomu; Tsuchida, Junko et al. (2018) Ceramide species are elevated in human breast cancer and are associated with less aggressiveness. Oncotarget 9:19874-19890
El-Rami, Fadi; Kong, Xiangzhen; Parikh, Hardik et al. (2018) Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis. Microbiology 164:173-185

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