Developmental funds have played a key role in facilitating scientific growth and increased interdisciplinary collaboration at Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) during the current funding period. Over the current funding cycle, $80,899 per year was awarded and expended on one new faculty recruitment, one pilot project per year, and support of the development of a Behavioral Measurement Shared Resource (BeMSR), which is being put forth as a competing shared resource as part of this renewal application. We are requesting $295,000 per year of CCSG support for our development program to recruit six new investigators over five years as part of planned expansions of Center programs, to fund up to three pilot projects per year, and to support the development of three new shared resource facilities. The faculty recruit supported by CCSG funds during the current funding period has already received support from NCI. MCC and institutional resources also provided support in the recruitment of 23 additional faculty members to VCU and MCC. Of these, eight have received new NCI funding (35%) with $6.8 M (direct costs, all years) and an additional $6.5 M (total direct costs, all years) in NIH and other extramural funding. Faculty positions and space for recruitment priorities for the next five years have been Identified. While the requested CCSG funds will be more than matched with MCC and institutional funds to accomplish these planned recruitments, pilot projects, and shared cores, the CCSG funds provide critical leverage to obtain matching funds from other institutional sources. Our pilot research project program received a total of 26 applications for the two most recent rounds of funding in 2010. Of these, 13 (50%) were awarded. Over the current funding period, a total of 63 applications were received for review, with a total of 27 (43%) approved for funding with 28.6% awarded in 2008-2009 resulting in extramural funding. The requested increase in CCSG funding will allow us to fund more of these key applications. Member surveys and Program discussions identified specific scientific member needs in the areas of lipidomics, high throughput sequencing, and imaging services. Once the need for each resource was agreed upon and endorsed by Dr Ginder, the identification of space, the acquisition of equipment, and the identification of potential directors was undertaken. Institutional commitment has also been secured to include the personnel required to launch the proposed activities.

Public Health Relevance

Developmental funds provided through the Cancer Center Support Grant insure essential resources are available to VCU Massey Cancer Center researchers to aid in programmatic development and scientific growth. These funds provide a basis to build interdisciplinary collaborations and foster new discoveries in cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016059-33
Application #
8662719
Study Section
Subcommittee B - Comprehensiveness (NCI)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
33
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Cantwell, Marc T; Farrar, Jared S; Lownik, Joseph C et al. (2018) STAT3 suppresses Wnt/?-catenin signaling during the induction phase of primary Myf5+ brown adipogenesis. Cytokine 111:434-444
Yamada, Akimitsu; Nagahashi, Masayuki; Aoyagi, Tomoyoshi et al. (2018) ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer. Mol Cancer Res 16:1059-1070
Volker, Sonja E; Hedrick, Shannon E; Feeney, Yvonne B et al. (2018) Cyclophilin A Function in Mammary Epithelium Impacts Jak2/Stat5 Signaling, Morphogenesis, Differentiation, and Tumorigenesis in the Mammary Gland. Cancer Res 78:3877-3887
Aqbi, Hussein F; Wallace, Matthew; Sappal, Samay et al. (2018) IFN-? orchestrates tumor elimination, tumor dormancy, tumor escape, and progression. J Leukoc Biol :
Durant, Stephen T; Zheng, Li; Wang, Yingchun et al. (2018) The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. Sci Adv 4:eaat1719
Li, Xiaojiaoyang; Liu, Runping; Huang, Zhiming et al. (2018) Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans. Hepatology 68:599-615
Wang, Feng; Li, Hongyan; Markovsky, Ela et al. (2018) Pazopanib radio-sensitization of human sarcoma tumors. Oncotarget 9:9311-9324
Damle, S R; Martin, R K; Cockburn, C L et al. (2018) ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production. Allergy 73:125-136
Stokes, Nancy A; Stanciu, Cristina E; Brocato, Emily R et al. (2018) Simplification of complex DNA profiles using front end cell separation and probabilistic modeling. Forensic Sci Int Genet 36:205-212
Poklepovic, Andrew; Qu, Yuesheng; Dickinson, Molly et al. (2018) Randomized study of doxorubicin-based chemotherapy regimens, with and without sildenafil, with analysis of intermediate cardiac markers. Cardiooncology 4:

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