Abstract

The goal of the Tissue Culture Facility is to provide all UNC Lineberger Comprehensive Cancer Center Members with expert services and quality controlled and innovative materials required for basic and clinical research involving in vitro cell culture and molecular biology needs. TCF services include four main """"""""divisions"""""""": Cell Culture (services and products), Clinical Support (through its Immortalization of Human Bcells using EBV and banking of patient samples in its Genetic Repository), Molecular Biology Materials Support (over 700 items available conveniently on site and 75,000 via free overnight shipping), and its large scale centralized cell production. The TCF is led by Stephen Oglesbee, Director, with over 27 years of directly related experience. The Core adds value to the Center by providing a range of specialized services, centralized functions, and cost savings and convenience. Highlights of research supported by the TCF include:a high human B-cell transformation rates (over 99%) and the development and testing of a new soon to be patented and/or licensed, significantly discounted isolation and growth medium for epithelial cells. Future plans for the TCF include expansion of its human B-cell immortalization program in support of numerous projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016086-30
Application #
7100661
Study Section
Subcommittee G - Education (NCI)
Project Start
2004-12-01
Project End
2009-11-30
Budget Start
2004-12-01
Budget End
2005-11-30
Support Year
30
Fiscal Year
2005
Total Cost
$121,856
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Zhang, Yugen; Dittmer, Dirk P; Mieczkowski, Piotr A et al. (2018) RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner. MBio 9:
Abida, Wassim; Sawyers, Charles L (2018) Targeting DNA Repair in Prostate Cancer. J Clin Oncol 36:1017-1019
Bigi, Rachele; Landis, Justin T; An, Hyowon et al. (2018) Epstein-Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A 115:E11379-E11387
Liu, Jianfang; Lichtenberg, Tara; Hoadley, Katherine A et al. (2018) An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics. Cell 173:400-416.e11
Song, Lixin; Dunlap, Kaitlyn L; Tan, Xianming et al. (2018) Enhancing Survivorship Care Planning for Patients With Localized Prostate Cancer Using a Couple-Focused mHealth Symptom Self-Management Program: Protocol for a Feasibility Study. JMIR Res Protoc 7:e51
Guseman, Alex J; Perez Goncalves, Gerardo M; Speer, Shannon L et al. (2018) Protein shape modulates crowding effects. Proc Natl Acad Sci U S A 115:10965-10970
Xu, Bowen; Cai, Ling; Butler, Jason M et al. (2018) The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells. Stem Cell Reports 10:675-683
Gartlan, Kate H; Bommiasamy, Hemamalini; Paz, Katelyn et al. (2018) A critical role for donor-derived IL-22 in cutaneous chronic GVHD. Am J Transplant 18:810-820
Lee, Andrew L; Sapienza, Paul J (2018) Thermodynamic and NMR Assessment of Ligand Cooperativity and Intersubunit Communication in Symmetric Dimers: Application to Thymidylate Synthase. Front Mol Biosci 5:47
Parada Jr, Humberto; Hall, Marissa G; Boynton, Marcella H et al. (2018) Trajectories of Responses to Pictorial Cigarette Pack Warnings. Nicotine Tob Res 20:876-881

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