Abstract

The goal of the Tissue Culture Facility is to provide all UNC Lineberger Comprehensive Cancer Center Members with expert services and quality controlled and innovative materials required for basic and clinical research involving in vitro cell culture and molecular biology needs. TCF services include four main """"""""divisions"""""""": Cell Culture (services and products), Clinical Support (through its Immortalization of Human Bcells using EBV and banking of patient samples in its Genetic Repository), Molecular Biology Materials Support (over 700 items available conveniently on site and 75,000 via free overnight shipping), and its large scale centralized cell production. The TCF is led by Stephen Oglesbee, Director, with over 27 years of directly related experience. The Core adds value to the Center by providing a range of specialized services, centralized functions, and cost savings and convenience. Highlights of research supported by the TCF include:a high human B-cell transformation rates (over 99%) and the development and testing of a new soon to be patented and/or licensed, significantly discounted isolation and growth medium for epithelial cells. Future plans for the TCF include expansion of its human B-cell immortalization program in support of numerous projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-31
Application #
7310746
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
31
Fiscal Year
2006
Total Cost
$125,512
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Schulfer, Anjelique F; Battaglia, Thomas; Alvarez, Yelina et al. (2018) Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Nat Microbiol 3:234-242
Hall, Marissa G; Mendel, Jennifer R; Noar, Seth M et al. (2018) Why smokers avoid cigarette pack risk messages: Two randomized clinical trials in the United States. Soc Sci Med 213:165-172
Cholon, Deborah M; Gentzsch, Martina (2018) Recent progress in translational cystic fibrosis research using precision medicine strategies. J Cyst Fibros 17:S52-S60
Tappata, Manaswita; Eluri, Swathi; Perjar, Irina et al. (2018) Association of mast cells with clinical, endoscopic, and histologic findings in adults with eosinophilic esophagitis. Allergy 73:2088-2092
Che, Tao; Majumdar, Susruta; Zaidi, Saheem A et al. (2018) Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell 172:55-67.e15
Hu, Peirong; Bi, Yanmin; Ma, Hong et al. (2018) Superior lentiviral vectors designed for BSL-0 environment abolish vector mobilization. Gene Ther 25:454-472
Townsley, Loni; Yannarell, Sarah M; Huynh, Tuanh Ngoc et al. (2018) Cyclic di-AMP Acts as an Extracellular Signal That Impacts Bacillus subtilis Biofilm Formation and Plant Attachment. MBio 9:
DeBono, Nathan L; Robinson, Whitney R; Lund, Jennifer L et al. (2018) Race, Menopausal Hormone Therapy, and Invasive Breast Cancer in the Carolina Breast Cancer Study. J Womens Health (Larchmt) 27:377-386
Okolie, Onyinyechukwu; Irvin, David M; Bago, Juli R et al. (2018) Intra-cavity stem cell therapy inhibits tumor progression in a novel murine model of medulloblastoma surgical resection. PLoS One 13:e0198596
van Haren, Jeffrey; Charafeddine, Rabab A; Ettinger, Andreas et al. (2018) Local control of intracellular microtubule dynamics by EB1 photodissociation. Nat Cell Biol 20:252-261

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