Abstract

The goals of the Animal Histopathology Core facility are to provide users with reliable, high quality, and cost-effective histologic services and to give investigators access to a board-certified veterinary pathologist Services include preparation of paraffin sections, histochemical staining, preparation of cryostat frozen sections, consultation and training in necropsy techniques and histopathologic assays, and provision of specialized equipment for use by investigators. The Core is directed by Virginia Godfrey, DVM, Ph.D, ACVP and the Faculty Advisor is Dr. David Lee. The Animal Histopathology Core supports a large number of Center members who use the mouse as a model system. Highlights of research supported by the Core include: analysis of knockout mice lacking CDKIs p18 and p27 by Dr. Yue Xiong (Cancer Cell Biology) and discovery of WT2 tumor suppressor gene by Dr. Bemard Weissman (Cancer Genetics). Future plans for the Core include access to another veterinary pathologist through interaction with the Mutant Mouse Regional Resource Center (MMRRC) and addition of limited immunohistochemistry services.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-31
Application #
7310754
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
31
Fiscal Year
2006
Total Cost
$124,132
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Suzuki, Aussie; Long, Sarah K; Salmon, Edward D (2018) An optimized method for 3D fluorescence co-localization applied to human kinetochore protein architecture. Elife 7:
Mohan, Vishwa; Sullivan, Chelsea S; Guo, Jiami et al. (2018) Temporal Regulation of Dendritic Spines Through NrCAM-Semaphorin3F Receptor Signaling in Developing Cortical Pyramidal Neurons. Cereb Cortex :
Haase, Karen P; Fox, Jaime C; Byrnes, Amy E et al. (2018) Stu2 uses a 15-nm parallel coiled coil for kinetochore localization and concomitant regulation of the mitotic spindle. Mol Biol Cell 29:285-294
Nicholls, Thomas J; Nadalutti, Cristina A; Motori, Elisa et al. (2018) Topoisomerase 3? Is Required for Decatenation and Segregation of Human mtDNA. Mol Cell 69:9-23.e6
Becker, Silke; Wang, Haibo; Simmons, Aaron B et al. (2018) Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms. Sci Rep 8:2003
Kim, R D; Alberts, S R; Peña, C et al. (2018) Phase I dose-escalation study of copanlisib in combination with gemcitabine or cisplatin plus gemcitabine in patients with advanced cancer. Br J Cancer 118:462-470
Chiang, Yun-Chen; Park, In-Young; Terzo, Esteban A et al. (2018) SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma. Cancer Res 78:3135-3146
Reuland, Daniel S; Cubillos, Laura; Brenner, Alison T et al. (2018) A pre-post study testing a lung cancer screening decision aid in primary care. BMC Med Inform Decis Mak 18:5
Kornides, Melanie L; McRee, Annie-Laurie; Gilkey, Melissa B (2018) Parents Who Decline HPV Vaccination: Who Later Accepts and Why? Acad Pediatr 18:S37-S43
Ramsingh, Arlene I; Gray, Steven J; Reilly, Andrew et al. (2018) Sustained AAV9-mediated expression of a non-self protein in the CNS of non-human primates after immunomodulation. PLoS One 13:e0198154

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