Abstract

The goal of the Tissue Culture Facility is to provide all UNC Lineberger Comprehensive Cancer Center Members with expert services and quality controlled and innovative materials required for basic and clinical research involving in vitro cell culture and molecular biology needs. TCF services include four main """"""""divisions"""""""": Cell Culture (services and products), Clinical Support (through its Immortalization of Human Bcells using EBV and banking of patient samples in its Genetic Repository), Molecular Biology Materials Support (over 700 items available conveniently on site and 75,000 via free overnight shipping), and its large scale centralized cell production. The TCF is led by Stephen Oglesbee, Director, with over 27 years of directly related experience. The Core adds value to the Center by providing a range of specialized services, centralized functions, and cost savings and convenience. Highlights of research supported by the TCF include:a high human B-cell transformation rates (over 99%) and the development and testing of a new soon to be patented and/or licensed, significantly discounted isolation and growth medium for epithelial cells. Future plans for the TCF include expansion of its human B-cell immortalization program in support of numerous projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016086-32
Application #
7426395
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
32
Fiscal Year
2007
Total Cost
$264,414
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Gourevitch, Rebecca A; Rose, Sherri; Crockett, Seth D et al. (2018) Variation in Pathologist Classification of Colorectal Adenomas and Serrated Polyps. Am J Gastroenterol 113:431-439
Park, Eliza M; Deal, Allison M; Yopp, Justin M et al. (2018) Understanding health-related quality of life in adult women with metastatic cancer who have dependent children. Cancer 124:2629-2636
Kasoji, Sandeep K; Rivera, Judith N; Gessner, Ryan C et al. (2018) Early Assessment of Tumor Response to Radiation Therapy using High-Resolution Quantitative Microvascular Ultrasound Imaging. Theranostics 8:156-168
Klein, Brianna J; Krajewski, Krzysztof; Restrepo, Susana et al. (2018) Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers. Epigenetics 13:683-692
Brewer, Noel T; Hall, Marissa G; Noar, Seth M (2018) Pictorial cigarette pack warnings increase quitting: a comment on Kok et al. Health Psychol Rev 12:129-132
Birken, Sarah A; Rohweder, Catherine L; Powell, Byron J et al. (2018) T-CaST: an implementation theory comparison and selection tool. Implement Sci 13:143
Ghosh, Arunava; Coakley, Raymond C; Mascenik, Teresa et al. (2018) Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome. Am J Respir Crit Care Med 198:67-76
Cheng, Ning; Watkins-Schulz, Rebekah; Junkins, Robert D et al. (2018) A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1-insensitive models of triple-negative breast cancer. JCI Insight 3:
Guseman, Alex J; Speer, Shannon L; Perez Goncalves, Gerardo M et al. (2018) Surface Charge Modulates Protein-Protein Interactions in Physiologically Relevant Environments. Biochemistry 57:1681-1684
Bhatt, Aadra P; Gunasekara, Dulan B; Speer, Jennifer et al. (2018) Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells. ACS Infect Dis 4:46-52

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