PROVIDED. Cancer Prevention and Control The Cancer Prevention and Control Program focuses on innovative research, aimed primarily on developing, rigorously testing, and disseminating evidence-based interventions and policy approaches that can improve cancer outcomes in North Carolina and beyond. The Program has breadth and depth in areas such as health disparities, community based participatory research, social and behavioral science, and translational research, and is committed to trans- and inter-disciplinary collaborations in order to foster new discoveries, conceptual models, methods, and strategies to reduce the burden of cancer in diverse populations and across the cancer continuum. Areas of excellence that are the ongoing Program themes include: cancer communication and decision making (including use of new technologies);health promotion and health disparities;cancer survivorship;and dissemination research. The Program is led by Dr. Marci Campbell, a nutritionist and behavioral scientist with extensive expertise in cancer prevention and control intervention research. The Program has grown to 38 members and is highly productive, with members publishing 1,183 peer-reviewed papers in the past five years. Of these, 11% were intra- and 16% inter-programmatic publications. Annual extramural funding (total costs) in 2009 totals $29.3 million, including $5.9 million in NCI funding. Program members are Pi's of three NCI funded pre- and post-doctoral training grants. Selected research accomplishments include demonstrating efficacy of tailored and internet-based interventions to improve physical activity, diet, and obesity, studying cancer risk communication e.g. for cancer screening and treatment decisions;designing and testing interventions to promote wellness and psychological health among cancer patients and survivors, tobacco control intervention and policy research, and cancer screening and care outcomes studies. The Program adds value in terms of integrative activities and opportunities for collaboration, access to resources such as the CHAI and Biostatistics Cores, space, seminars, retreats, and training and education. Future directions include an emphasis on faculty recruitment in areas such as health communication and health outcomes, translational research using resources such as the UNC Health Registry Cancer Survivorship Study enhancing breadth and depth in current thematic areas;increased focus on health outcomes;and a state-wide research infrastructure project to optimize cancer outcomes in North Carolina.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016086-35
Application #
8340246
Study Section
Subcommittee G - Education (NCI)
Project Start
2011-05-23
Project End
2015-11-30
Budget Start
2011-05-23
Budget End
2011-11-30
Support Year
35
Fiscal Year
2011
Total Cost
$187,171
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Cai, Ling; Tsai, Yi-Hsuan; Wang, Ping et al. (2018) ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer. Mol Cell 72:341-354.e6
Moschos, Stergios J; Sullivan, Ryan J; Hwu, Wen-Jen et al. (2018) Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors. JCI Insight 3:
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Sun, Junjiang; Shao, Wenwei; Chen, Xiaojing et al. (2018) An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs. Mol Ther Methods Clin Dev 10:257-267
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Waters, Andrew M; Der, Channing J (2018) KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer. Cold Spring Harb Perspect Med 8:
Gralinski, Lisa E; Sheahan, Timothy P; Morrison, Thomas E et al. (2018) Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis. MBio 9:
Au, Kin Man; Tripathy, Ashutosh; Lin, Carolina Pe-I et al. (2018) Bespoke Pretargeted Nanoradioimmunotherapy for the Treatment of Non-Hodgkin Lymphoma. ACS Nano 12:1544-1563
Mirlekar, Bhalchandra; Michaud, Daniel; Searcy, Ryan et al. (2018) IL35 Hinders Endogenous Antitumor T-cell Immunity and Responsiveness to Immunotherapy in Pancreatic Cancer. Cancer Immunol Res 6:1014-1024

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