SHARED RESOURCE MANAGEMENT The Lineberger Comprehensive Cancer Center has a strong history of providing high quality and cost-effective shared resources that offer innovative services and technologies to the membership. The oversight of the SRs involves the Director, Deputy Director, and Associate Directors of the Center. Program leaders also provide valuable input and guidance on the services offered. Center members provide feedback through surveys and serve on SR active internal advisory boards for each SR. Over the last five years, this management process has provided substantial new infrastructure for the faculty including: 1) an expanded and more robust tissue- based research pipeline for correlative work, 2) new technologies such as single cell analysis, mass spec cytometer instrumentation, and a CyroEM, 3) expanded faculty SR leadership expertise in pathology and biostatistics. The financial and administrative oversight is provided by the Associate Director of Administration and his staff of 4 FTEs devoted to this endeavor. The SRs are well managed and are well used as demonstrated by these statistics: ? 97% of 2018 user-survey respondents stated the SR overall experience was excellent or good. ? 81% of LCCC Members used a Shared Resource in FY19 ? 82% of FY19 total LCCC managed-Shared Resource users were Center faculty Importantly, the SRs are cost-effective and provide exceptional value to the members. The Center requests 8% of the operating budget for the SRs from the CCSG. This is greatly leveraged through a sustained annual institutional commitment of over $10M in operational support, 37% of the total SR operating budget. The remaining SR operating budget, approximately $14.3M, is recovered by recharge mechanisms. As a result of the CCSG and institutional commitment, members receive discounts on fees, priority access and free consultative services.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016086-45
Application #
10089825
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-06-01
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
45
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Little, Michael S; Pellock, Samuel J; Walton, William G et al. (2018) Structural basis for the regulation of ?-glucuronidase expression by human gut Enterobacteriaceae. Proc Natl Acad Sci U S A 115:E152-E161
Knott, Simon R V; Wagenblast, Elvin; Khan, Showkhin et al. (2018) Erratum: Asparagine bioavailability governs metastasis in a model of breast cancer. Nature 556:135
Anderson, Chelsea; Smitherman, Andrew B; Nichols, Hazel B (2018) Conditional relative survival among long-term survivors of adolescent and young adult cancers. Cancer 124:3037-3043
Liu, Meng-Xi; Jin, Lei; Sun, Si-Jia et al. (2018) Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene 37:1637-1653
Curtis 2nd, Alan D; Jensen, Kara; Van Rompay, Koen K A et al. (2018) A simultaneous oral and intramuscular prime/sublingual boost with a DNA/Modified Vaccinia Ankara viral vector-based vaccine induces simian immunodeficiency virus-specific systemic and mucosal immune responses in juvenile rhesus macaques. J Med Primatol 47:288-297
Williams, Lindsay A; Nichols, Hazel B; Hoadley, Katherine A et al. (2018) Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study. Cancer Causes Control 29:25-32
Amunugama, Ravindra; Willcox, Smaranda; Wu, R Alex et al. (2018) Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading. Cell Rep 23:3419-3428
Evangelista, Flor; Roth, Aleeza J; Prisayanh, Phillip et al. (2018) Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. J Autoimmun 89:171-185
Sin, Sang-Hoon; Eason, Anthony B; Bigi, Rachele et al. (2018) Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Renders B Cells Hyperresponsive to Secondary Infections. J Virol 92:
Dellon, Evan S; Selitsky, Sara R; Genta, Robert M et al. (2018) Gene expression-phenotype associations in adults with eosinophilic esophagitis. Dig Liver Dis 50:804-811

Showing the most recent 10 out of 1525 publications